Yokota et al., Int Immunol 2009
:
Equivalent levels of aldehyde dehydrogenase activity ( ALDHact ) and ALDH1A2 expression were induced synergistically by GM-CSF and IL-4 in splenic DCs in vitro
Samson et al., Inflamm Bowel Dis 2011
(Crohn Disease...) :
In the murine model, GM-CSF blockade alone induced IEC CCL25 expression, and reduced the frequency of mesenteric lymph node (MLN) CD4 ( + ) FOXP3 ( + ) cells, while Card15 deficiency alone enhanced MLN DC RALDH2 expression
Iwata et al., Vitam Horm 2011
:
RA itself is essential for the GM-CSF induced RALDH2 expression ... Toll-like receptor mediated signals can also enhance the GM-CSF induced RALDH2 expression in immature DCs