◀ Back to CAPN1
CAPN1 — MMP14
Text-mined interactions from Literome
Li et al., Diabetes 2011
(Cardiomyopathy, Hypertrophic...) :
In cultured cardiac fibroblasts, high glucose induced proliferation and
MMP activities were
prevented by
calpain inhibition
Subramanian et al., J Cardiovasc Pharmacol 2012
(Aortic Aneurysm, Abdominal...) :
Inhibition of
calpain , a calcium activated neutral cysteine protease, by overexpression of its endogenous inhibitor, calpastatin,
attenuates AngII induced leukocyte infiltration, perivascular inflammation, and
MMP activation in mice
Kang et al., J Biol Chem 2011
(Neovascularization, Pathologic) :
S1P and WSS synergistically activated
MT1-MMP and induced cell membrane localization of MT1-MMP in a
calpain dependent manner
Singh et al., Can J Physiol Pharmacol 2012
(Anoxia...) :
On the other hand, inhibition of
calpain activity upon treatment with leupeptin or MDL 28170 significantly
reduced the
MMP activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity
Kwak et al., Angiogenesis 2012
:
Both
calpain and vimentin were
required for successful
MT1-MMP membrane translocation, which was stimulated by S1P ... In addition, vimentin complexed with MT1-MMP in a manner that required both the cytoplasmic domain of
MT1-MMP and
calpain activation , which increased the soluble pool of vimentin in endothelial cells