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BCL2 — PRKCA
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Leirdal et al., Br J Cancer 1999
(Brain Neoplasms...) :
The inhibition of
PKC alpha gene expression by the ribozyme
resulted in a significant reduction in
Bcl-xL gene expression, a protein that inhibits apoptosis and is overexpressed in glioma cells
Hsueh et al., Cancer Chemother Pharmacol 2000
:
Protein expression of COX-2 and
Bcl-2 and
activation of
PKCalpha were examined by Western blot analysis
Deng et al., J Natl Cancer Inst Monogr 2001
(Leukemia, Myeloid...) :
However, we have recently found that high concentrations of staurosporine up to 1 microM : can only partially inhibit IL-3 stimulated Bcl2 phosphorylation but completely block
PKCalpha mediated
Bcl2 phosphorylation in vitro, indicating the existence of a non-PKC, staurosporine-resistant Bcl2 kinase ( SRK )
Jiffar et al., Leukemia 2004
(Precursor Cell Lymphoblastic Leukemia-Lymphoma) :
The failure of PKC alpha overexpression to activate non-Bcl2 survival pathways suggested that
PKC alpha mediated chemoresistance
requires Bcl2
Ruvolo et al., J Biol Chem 1998
:
A functional
role for mitochondrial
protein kinase Calpha in
Bcl2 phosphorylation and suppression of apoptosis