Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
BCL2
→
IL18
(decreases)
Chandrasekar et al., Biochem Biophys Res Commun 2006* Evidence: Treatment with IL-18 induced the translocation of the pro-apoptotic protein bax from the cytosol to the mitochondrial fraction, stimulated the release of cytochrome c from the mitochondria, and reduced the total cellular levels of bcl-2 (Fig. 1B).