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APOB — DDAH2
Text-mined interactions from Literome
Ito et al., Circulation 1999
(Hypercholesterolemia) :
Accordingly, we studied the
effects of oxidized
LDL ( oxLDL ) or tumor necrosis factor-alpha (TNF-alpha) on the accumulation of ADMA by transformed human umbilical vein endothelial cells ( ECV304 ) and on the enzyme
dimethylarginine dimethylaminohydrolase ( DDAH ), which degrades ADMA
Jiang et al., Acta Pharmacol Sin 2004
:
In cultured ECV304 cells, LDL or
ox-LDL markedly
increased the level of ADMA and TNF-alpha and potentiated the adhesion of monocytes to endothelial cells, concomitantly with a significantly decrease in the activity of
DDAH and serum level of NO
Jiang et al., J Ethnopharmacol 2004
:
DMB also significantly reduced the decreased activity of dimethylarginine dimethylaminohydrolase (
DDAH )
induced by
LDL in cultured endothelial cells
Xie et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2006
:
Pretreatment with losartan ( 10 ( -8 ) - 10 ( -6 ) mmol/L ) significantly inhibited the increased levels of ADMA, LDH and TNF-alpha, attenuated the decreased levels of NO and the decreased activity of
DDAH induced by
ox-LDL ( P < 0.05 )
Tan et al., Vascul Pharmacol 2007
:
Taurine ( 1 or 5 microg/ml ) significantly attenuated the increases in the levels of LDH, ADMA, TNF-alpha and MDA, and the decrease in the level of NO and the activity of
DDAH induced by
ox-LDL in HUVECs