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AKT2 — TRIB3

Pathways - manually collected, often from reviews:

• Reactome Reaction: AKT2 → TRIB3 (reaction) Maira et al., Science 2001*, Du et al., Science 2003*, James et al., Biochem J 1996*, Stephens et al., Science 1998*
• Reactome Reaction: AKT2 → TRIB3 (direct_complex)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: TRIB3 — AKT2 (in vivo) Du et al., Science 2003*
• IRef Hprd Interaction: TRIB3 — AKT2 (in vitro) Du et al., Science 2003*

Text-mined interactions from Literome

Koo et al., Nat Med 2004 (Diabetes Mellitus, Type 2...) : Hepatic insulin sensitivity was enhanced in PGC-1-deficient mice, reflecting in part the reduced expression of the mammalian tribbles homolog TRB-3 , a fasting-inducible inhibitor of the serine-threonine kinase Akt/PKB ( ref. 6 )
Prudente et al., J Clin Endocrinol Metab 2009 (Diabetes Mellitus, Type 2) : TRIB3 inhibits insulin stimulated Akt phosphorylation and subsequent insulin action
Liu et al., Am J Physiol Endocrinol Metab 2010 (Diabetes Mellitus, Type 2...) : Tribbles homolog 3 (TRIB3) was found to inhibit insulin stimulated Akt phosphorylation and modulate gluconeogenesis in rodent liver
Salazar et al., Biochim Biophys Acta 2013 (Neoplasms, Experimental) : Our data support the idea that THC induced TRIB3 up-regulation inhibits AKT phosphorylation by regulating the accessibility of AKT to its upstream activatory kinase ( the mammalian target of rapamycin complex 2 ; mTORC2 )