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AKT2 — KLK3
Text-mined interactions from Literome
Kochuparambil et al., J Pharmacol Exp Ther 2011
(Neoplasm Invasiveness...) :
Our findings demonstrate the therapeutic benefits of simvastatin for prostate cancer and suggest a link between simvastatin,
regulation of
Akt activity, and
PSA expression in prostate tumors
Iguchi et al., J Androl 2012
:
Inhibition of
Akt phosphorylation by the phosphatidylinositol 3-kinase inhibitor LY294002
resulted in reduction of
PSA expression in LNCaP cells ... Conversely, activation of
Akt by serum starvation
led to the induction of
PSA expression in LNCaP-E9 cells
Ye et al., Zhong Xi Yi Jie He Xue Bao 2011
(Breast Neoplasms) :
To investigate the
effects of
Astragalus polysaccharide (APS) on proliferation of basal-like breast cancer cell line MDA-MB-468 cells and
Akt phosphorylation in MDA-MB-468 cells ... For observing the
effects of
APS on
phosphor-Akt ( p-Akt ), in-cell Western blot method was used after 1, 2, 4 and 7 d of culture in APS to detect protein expressions of p-Akt ( Thr308 ) and p-Akt ( Ser473 ) ... After silencing PTEN gene by siRNA,
APS could not
mediate Akt phosphorylation