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NOTCH1 — NRARP
Text-mined interactions from Literome
Krebs et al., Dev Biol 2001
:
Thus,
Nrarp transcript levels are
regulated by the level of
Notch1 signaling in both cultured cell lines and mouse embryos
Pirot et al., Biochem Biophys Res Commun 2004
:
Interestingly, increased
Nrarp transcription was
observed following induction of
Notch signaling, suggesting the existence of a negative feedback loop
Ishitani et al., Nat Cell Biol 2005
:
These findings reveal that
Nrarp independently
regulates canonical Wnt and
Notch signalling by modulating LEF1 and Notch protein turnover, respectively
Van de Walle et al., Blood 2009
:
High
Notch activity
increases DTX1,
NRARP , and RUNX3 expression, genes that are down-regulated during alphabeta-lineage differentiation
Sewell et al., Dev Biol 2009
:
These include Uncx, a somite gene required for rib and vertebral patterning, and
Nrarp , a
regulator of
Notch/Wnt signaling in zebrafish and a cycling gene in mouse