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IL4 — NOTCH1
Text-mined interactions from Literome
Okamoto et al., J Immunol 2009
(Bronchial Hyperreactivity...) :
These data identify the essential
role of the interactions between
Notch on CD4 ( + ) T cells and Jagged1 on APCs in the initiation of
IL-4 production and Th2 differentiation for the development of AHR and allergic airway inflammation
Watarai et al., Blood 2010
:
Interestingly, in the
presence of
Notch signals, NKT-ES cells differentiated only to thymic CD44 ( lo ) CD24 ( hi ) NKT cells producing mainly
interleukin-4 (IL-4) , whereas NKT cells resembling CD44 ( hi ) CD24 ( lo ) liver NKT cells producing mainly interferon gamma (IFN-gamma) and exhibiting strong adjuvant activity in vivo were developed in the switch culture starting at day 14 in the absence of Notch