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IGF1R — ZGLP1
Text-mined interactions from Literome
Cornu et al., J Biol Chem 2010
:
Here, we further investigated how
GLP-1 induces
IGF-1R expression and whether the IGF-2/IGF-1R autocrine loop is also involved in mediating GLP-1-increase in glucose competence and proliferation ... We show that
GLP-1 up-regulated
IGF-1R expression by a protein kinase A-dependent translational control mechanism, whereas isobutylmethylxanthine, which led to higher intracellular accumulation of cAMP than GLP-1, increased both IGF-1R transcription and translation
Cornu et al., Islets 2009
:
Using MIN6 and primary islet cells, we demonstrated that
GLP-1 strongly
stimulates IGF-1R expression and that activation of the IGF-1R/Akt signaling pathway required active secretion of IGF-2 by the ß-cells