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MUC16 — UTP18
Text-mined interactions from Literome
Choi et al., Acta Otolaryngol 2003
:
Extracellular
uridine 5'-triphosphate ( UTP ) regulates a variety of biological functions in the airway epithelium, including chloride and fluid transport, mucociliary clearance and
mucin secretion via the P2Y purinergic receptors ... Apically applied
UTP induced increased
mucin and lysozyme secretion, as measured by dot blotting ... In contrast,
UTP did not
enhance mucin and lysozyme mRNA expression until 72 h after treatment
Choi et al., Acta Otolaryngol 2003
:
We also examined the
effect of
UTP ( an agonist for P2Y2 ) and ATPgammaS ( an agonist for P2Y11 ) on mucin secretion and
mucin gene expression ...
UTP and ATPgammaS increased [ Ca2+ ] i via caffeine-sensitive pathways, and these two agonists
stimulated mucin secretion to a similar magnitude without their gene enhancement
Lu et al., Am J Physiol Lung Cell Mol Physiol 2005
:
Our results showed that in primary RTSE cells, DEX 1 ) dose dependently suppressed Muc5ac mRNA levels, but the levels of cellular Muc5ac protein and HMW mucins were unaffected ; 2 ) did not affect constitutive or
UTP stimulated
mucin secretion ; 3 ) enhanced the translation of Muc5ac ; and 4 ) increased the stability of intracellular Muc5ac protein by a mechanism other than the inhibition of the proteasomal degradation
Choi et al., Hear Res 2005
(Calcium Signaling) :
UTP induced
mucin secretion was quantified by an immunoblotting assay ...
UTP induced
mucin secretion was inhibited by a Ca ( 2+ ) chelating agent, BAPTA-AM, and was stimulated by ionomycin ...
UTP induced
mucin secretion was also suppressed by U73122 and 2-APB, while Calphostin C suppressed it to a small extent and PD98059 was ineffective ...
UTP induced
mucin secretion in NHMEE cells is strongly dependent on Ca ( 2+ ) - and IP ( 3 )
Abdullah et al., Am J Physiol 1997
:
Airway goblet cells secrete
mucin in
response to ATP and
uridine 5'-triphosphate ( UTP ) , but the underlying signal transduction pathways are poorly understood ... PKC inhibitors were relatively ineffective against PMA- and
UTP induced
mucin secretion
Nguyen et al., Am J Physiol 1998
:
We observed that 1 ) ATP,
UTP , adenosine 5'-O- ( 3-thiotriphosphate ), and, to a lesser extent, beta, gamma-methylene-ATP, but not adenosine,
stimulated 125I- efflux from PDEC, suggesting a primary role for P2Y2 receptors, 2 ) ATP stimulated 125I- efflux was inhibited by 5-nitro-2- ( 3-phenylpropylamino ) benzoic acid, diphenylamine-2-carboxylate, and DIDS, suggesting mediation through Ca2+ activated Cl- channels, 3 ) ATP stimulated an 86Rb+ efflux sensitive to BaCl2 and charybdotoxin, thus likely occurring through Ca2+ activated K+ channels, 4 ) serosal or luminal addition of UTP activated apical Cl- conductance and basolateral K+ conductance when nystatin permeabilized PDEC were studied in an Ussing chamber, suggesting the expression of P2Y2 receptors on both sides of the cell, 5 ) ATP stimulated
mucin secretion, and 6 ) ATP increases intracellular Ca2+ concentration ([Ca2+]i)