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HSPD1 — TLR2

Pathways - manually collected, often from reviews:

• NCI Pathway Database Endogenous TLR signaling: TLR1 (TLR1) → HSP60/TLR2/TLR1 complex (TLR2-TLR1-HSPD1) (modification, collaborate)
  Zanin-Zhorov et al., FASEB J 2003*
  Evidence: mutant phenotype
• NCI Pathway Database Endogenous TLR signaling: TLR2 (TLR2) → HSP60/TLR2/TLR1 complex (TLR2-TLR1-HSPD1) (modification, collaborate)
  Zanin-Zhorov et al., FASEB J 2003*
  Evidence: mutant phenotype
• NCI Pathway Database Endogenous TLR signaling: TLR2 (TLR2) → HSP60 (HSPD1) (modification, collaborate) Zanin-Zhorov et al., FASEB J 2003*
  Evidence: mutant phenotype
• NCI Pathway Database Endogenous TLR signaling: HSP60/TLR2/TLR1 complex (TLR2-TLR1-HSPD1) → HSP60 (HSPD1) (modification, collaborate) Zanin-Zhorov et al., FASEB J 2003*
  Evidence: mutant phenotype

Text-mined interactions from Literome

Da Costa et al., Eur J Immunol 2004 (Chlamydophila Infections) : In conclusion, HSP60 from C. pneumoniae triggers inflammatory responses in vivo that differ from responses induced by endotoxin or CpG oligonucleotides and are dependent on TLR2 and 4
Kim et al., Bone 2009 (Bone Resorption) : Furthermore, Western blotting showed that HSP60 up-regulated TLR-2 and TLR-4 expression, and pretreatment with blocking antibodies for TLR-2 and TLR-4 almost completely eliminated the effects of HSP60 on apoptosis, caspase-3 and -9 activation, and activation of NFkappaB and p38 MAPK ... In conclusion, up-regulation of TLR-2 by HSP60 may play a critical role in promoting bone loss in the estrogen-deficient state
Yang et al., PloS one 2009 (Lung Neoplasms...) : Importantly, heat shock protein 60 released by tumor cells caused a persistent activation of TLR2 and was critical in the constitutive activation of transcription factor Stat3, leading to the release of immunosuppressive cytokines and chemokines