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PDGFA — SLC9A1
Text-mined interactions from Literome
Schneider et al., J Cell Biol 2009
:
In growth arrested NIH3T3 cells,
NHE1 is
activated by the specific PDGFR-alpha ligand
PDGF-AA
Clement et al., J Cell Sci 2013
(MAP Kinase Signaling System) :
PDGF-AA mediated activation of the dimerized ciliary receptor produces a phosphorylation cascade through the PI3K-AKT and MEK1/2-ERK1/2 pathways leading to the activation of the Na ( + ) /H ( + ) exchanger,
NHE1 , cytoplasmic alkalinization and actin nucleation at the lamellipodium that supports directional cell migration