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GJA1 — RAC1
Text-mined interactions from Literome
Matsuda et al., J Mol Cell Cardiol 2006
:
Furthermore, the translocation of
Cx43 to longitudinal cell termini was
prevented by the inhibition of
Rac1 , but not RhoA
Adam et al., J Am Coll Cardiol 2010
(Atrial Fibrillation...) :
In neonatal rat cardiomyocytes and fibroblasts, a specific small molecule inhibitor of
Rac1 or simvastatin completely
prevented the angiotensin II-induced up-regulation of CTGF,
Cx43 , and N-cadherin expression ... Angiotensin II activates CTGF via
activation of
Rac1 and nicotinamide adenine dinucleotide phosphate oxidase, leading to up-regulation of
Cx43 , N-cadherin, and interstitial fibrosis and therefore contributing to the signal transduction of atrial structural remodeling