Gene interactions and pathways from curated databases and text-mining

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NR3C1 — RB1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: Complex of NR3C1-SMARCA4 → RB1 (increases) Marshall et al., J Biol Chem 2003*
    Evidence: In contrast, RB enhances association of the glucocorticoid receptor (GR) with either BRG1 or hBRM, thus resulting in increased GR activity (51-53). The association between BRG1 or hBRM and GR is known to be direct, and recruitment of SWI/SNF complexes to GR may actually stimulate displacement of GR from chromatin, allowing GR to return to the remodeled chromatin with additional transcription factors (30).
  • OpenBEL Selventa BEL large corpus: Complex of NR3C1-SMARCA4 → RB1 (increases) Marshall et al., J Biol Chem 2003*
    Evidence: RB enhances association of the GR with either BRG1 or BRM, resulting in increased GR activity