◀ Back to NOTCH4
FBXW7 — NOTCH4
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
NOTCH4
→
Complex of CUL1-FBXW7-RBX1-SKP1
(decreases)
Evidence: The involvement of Fbw7 in the control of the Notch pathway is confirmed by the finding that Notch4 accumulates in Fbw7-deficient embryos, which die in utero at embryonic day 10.5 and manifest abnormal vascular development
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wu et al., Mol Cell Biol 2001
:
We show here that the F-box/WD40 repeat protein
SEL-10 negatively
regulates Notch receptor activity by targeting the intracellular domain of Notch receptors for ubiquitin mediated protein degradation
Fujii et al., Cancer Sci 2006
(Breast Neoplasms) :
Fbxw7 contributes to the ubiquitin mediated degradation of cyclin E, c-Myc, Aurora-A,
Notch and c-Jun, all of which appear to function as cell-cycle promoters and oncogenic proteins
Matsumoto et al., J Biol Chem 2011
:
Fbxw7 dependent degradation of
Notch is required for control of `` stemness '' and neuronal-glial differentiation in neural stem cells
Snyder et al., Neural development 2012
:
Fbxw7 regulates
Notch to control specification of neural precursors for oligodendrocyte fate
Hubbard et al., Genes Dev 1997
(Cell Transformation, Neoplastic) :
We propose that SEL-10 promotes the ubiquitin mediated turnover of LIN-12/Notch proteins, and discuss potential roles for the
regulation of
lin-12/Notch activity by
sel-10 in cell fate decisions and tumorigenesis