◀ Back to NFKB1
NFKB1 — RHOB
Text-mined interactions from Literome
Fritz et al., J Biol Chem 2001
:
Ras related GTPase
Rhob represses
NF-kappaB signaling ... However,
RhoB inhibited both basal and genotoxic agent stimulated activity of the transcription factor
nuclear factor kappaB (NF-kappaB) ... Thus,
RhoB attenuated alkylation induced increase in the DNA binding activity of NF-kappaB and abrogated
NF-kappaB-driven gene expression ... This indicates that
RhoB represses
NF-kappaB activation by inhibiting dissociation and subsequent degradation of IkappaBalpha
Rodriguez et al., Cell Signal 2007
:
ROCK I-mediated
activation of
NF-kappaB by
RhoB ... Here we show that
RhoB can
activate NF-kappaB signaling in multiple cell types ... Whereas
RhoB-F is a potent
activator of
NF-kappaB , much weaker activation is observed for RhoB-GG, RhoA, and RhoC ...
NF-kappaB activation by
RhoB is not associated with increased nuclear translocation of RelA/p65, but rather, by modification of the RelA/p65 transactivation domain ...
Activation of
NF-kappaB by
RhoB is dependent upon ROCK I but not PRK I ... Suppression of
RhoB activity by dominant-inhibitory mutants, or siRNA,
blocks NF-kappaB activation by Bcr, and TSG101, but not by TNFalpha or oncogenic Ras