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DDC — MMP1

Text-mined interactions from Literome

Tanioka et al., J Gastroenterol Hepatol 2006 : DDC activated PSC, increasing the number of alpha-SMA positive cells, enhancing secretion of type I collagen and MMP , inhibiting PSC proliferation
Liu et al., Biosci Rep 2013 : However, the effect of DDC on MMP-1 ( matrix metalloproteinase-1 ), which is the main collagen degrading matrix metalloproteinase, has not been reported ... In co-culture experiments, we found that DDC significantly enhanced MMP-1 expression in human HSC ( LX-2 ) that were cultured with hepatocyte C3A cells either expressing or not expressing CYP2E1 ... H2O2 treatment abrogated DDC induced MMP-1 up-regulation and collagen I decrease, while catalase treatment slightly up-regulated MMP-1 expression ... The ERK1/2 inhibitor ( U0126 ) and Akt inhibitor ( T3830 ) abrogated the DDC induced MMP-1 up-regulation ... The enhancement of MMP-1 expression by DDC was associated with H2O2 inhibition and coordinated regulation by the ERK1/2 and Akt pathways