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MDM2 — XRCC6

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: XRCC6 — MDM2 (direct interaction, enzymatic study) Gama et al., Cell Death Differ 2009*
• IRef Biogrid Interaction: XRCC6 — MDM2 (physical association, affinity chromatography technology) Gama et al., Cell Death Differ 2009*
• IRef Biogrid Interaction: XRCC6 — MDM2 (direct interaction, pull down) Gama et al., Cell Death Differ 2009*

Text-mined interactions from Literome

Gama et al., Cell Death Differ 2009 : Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2 dependent Ku70 destabilization ... We found that Hdm2 ( human homolog of murine double minute ) has an ability to ubiquitinate Ku70 and that Hdm2 overexpression in cultured cells causes a decrease in Ku70 expression levels ... We found that VEGF stimulated nuclear translocation of Hdm2 in EC and efficiently inhibited Ku70 degradation
Mayo et al., Cancer Res 1997 : The data support a model by which DNA-PK activation by DNA damage and phosphorylation of Mdm-2 renders the Mdm-2 protein unable to inhibit p53 transactivation, resulting in cell cycle arrest