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MAP3K1 — MAPK9

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAPK9 → MAP3K1 (directlyIncreases, MAP3K1 Activity, MAPK9 Activity)
  Evidence: Summary The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses.
• KEGG RIG-I-like receptor signaling pathway: MAP3K1 → MAPK10/MAPK8/MAPK9 (protein-protein, activation)
• WikiPathways RIG-I-like Receptor Signaling: MAP3K1 → Complex of MAPK10-MAPK9 (activation)
• WikiPathways BMP Signaling Pathway in Eyelid Development: MAP3K1 → MAPK9 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAP3K1 — MAPK9 (direct interaction, two hybrid) Gallagher et al., J Biol Chem 2004*
• IRef Biogrid Interaction: MAP3K1 — MAPK9 (direct interaction, pull down) Gallagher et al., J Biol Chem 2002*

Text-mined interactions from Literome

Uhlik et al., Biochem Cell Biol 2004 (MAP Kinase Signaling System) : Wiring diagrams of MAPK regulation by MEKK1 , 2, and 3
Korchnak et al., Cell Signal 2009 : Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase ( MAP3K ) that activates multiple mitogen activated protein kinase ( MAPK ) pathways in response to growth factors, stresses and the pro-inflammatory cytokine, tumor necrosis factor (TNF)
Xu et al., Proc Natl Acad Sci U S A 1995 : MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen activated protein kinase