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HSPA5 — MAPK9

Text-mined interactions from Literome

Ou et al., Eur J Pharmacol 2007 (Carcinoma, Renal Cell...) : Selective inhibitors of ERK, p38 MAPK , and JNK suppressed the induction of GRP78 , CHOP, and PPAR-beta, attenuated indomethacin induced cytotoxicity and reduced increased caspase activity
Yang et al., J Biol Chem 2007 (Diabetes Mellitus) : Inhibition of p38 MAPK , but not of ERK1/2, inhibited the expression of BiP and CHOP and decreased H2S stimulated apoptosis, suggesting that p38 MAPK activation functions upstream of ER stress to initiate H2S induced apoptosis
Park et al., Biochem Pharmacol 2011 : However, these MG132 induced apoptotic events, with the exceptions of upregulation of Grp78/BiP and CHOP/GADD153 and activation of JNK and p38MAPK , were abrogated by overexpression of Bcl-xL ... Pretreatment with the pan-caspase inhibitor z-VAD-fmk prevented MG132 induced apoptotic caspase cascade, but allowed upregulation of Grp78/BiP and CHOP/GADD153 levels, activation of JNK and p38MAPK , d?m loss, and cleavage of procaspase-9 ( 47kDa ) to active form ( 35kDa )