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MAPK1 — PTPN6

Pathways - manually collected, often from reviews:

• KEGG Leishmaniasis: PTPN6 → MAPK1/MAPK3 (protein-protein, inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 48 proteins (physical association, tandem affinity purification) Brown et al., J Cell Biochem 2008

Text-mined interactions from Literome

Kumar et al., J Biol Chem 1999 : Furthermore, in contrast to the phosphatase-dead SHPTP1 C453S mutant, overexpression of wild-type SHPTP1 blocks interaction of RAFTK with the SH2-domain of c-Src and inhibits RAFTK mediated MAPK activation
Gomez et al., Science signaling 2009 (Leishmaniasis) : Upon Leishmania-macrophage interaction, activation of the protein tyrosine phosphatase (PTP) SHP-1 rapidly leads to the down-regulation of Janus kinase and mitogen activated protein kinase signaling, resulting in the attenuation of host innate inflammatory responses and of various microbicidal macrophage functions
Bennett et al., Mol Cell Biol 1996 : Overexpression of catalytically inactive SHPTP2 ( PTP2CS ) but not catalytically inactive SHPTP1 , inhibited mitogen activated protein ( MAP ) kinase activation and Elk-1 transactivation following epidermal growth factor (EGF) stimulation of 293 cells
Su et al., J Biol Chem 1996 : Similarly, the phosphorylation of the mitogen activated protein kinase and mitogen activated protein kinase kinase activity was markedly inhibited by overexpression of mutant PTP1C