UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

NCI Pathway Database S1P1 pathway: Erk1-2 (MAPK3/MAPK1) → S1P1/S1P/Gi complex (S1PR1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1) (modification, collaborate)
Van Brocklyn et al., Cancer Lett 2002
Evidence: mutant phenotype, assay
NCI Pathway Database S1P1 pathway: S1P1/S1P/Gi complex (S1PR1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1) → Erk1-2-active (MAPK3/MAPK1) (modification, activates)
Van Brocklyn et al., Cancer Lett 2002
Evidence: mutant phenotype, assay
NCI Pathway Database S1P4 pathway: Erk1-2 (MAPK3/MAPK1) → S1P/S1P4/Gi complex (S1PR4-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1) (modification, collaborate)
Van Brocklyn et al., J Biol Chem 1999
Evidence: mutant phenotype, assay
NCI Pathway Database S1P3 pathway: Erk1-2 (MAPK3/MAPK1) → S1P/S1P3/Gi complex (S1PR3-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1) (modification, collaborate)
Baudhuin et al., FASEB J 2004
Evidence: mutant phenotype, assay
NCI Pathway Database S1P2 pathway: Erk1-2 (MAPK3/MAPK1) → S1P/S1P2/Gi complex (S1PR2-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1) (modification, collaborate)
An et al., J Biol Chem 2000, Arikawa et al., J Biol Chem 2003, Gonda et al., Biochem J 1999
Evidence: mutant phenotype, assay
WikiPathways Signal Transduction of S1P Receptor: GNAI1/GNAI2/GNAI3 → MAPK3/MAPK1/MAPK6/MAPK4/MAPK7/MAPK12 (activation)