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IL6 — MAP2K1

Text-mined interactions from Literome

Chae et al., Pharmacol Res 2001 : In contrast, PD98059, a specific inhibitor of MEK1 , had no effect on NO and IL-6 release
Gobert et al., J Biol Chem 2004 : In contrast, inhibitors of protein kinase A or C, mitogen activated protein kinase kinase , and phosphoinositide 3-kinase had no effect on IL-6 mRNA levels
Lewthwaite et al., Int Immunopharmacol 2007 (Inflammation) : Selective inhibitors of p38 ( mapk ) ( SB203580 ) or of MEK1/2 , the direct upstream activator of ERK1/2 ( PD98059 ), reduced the synthesis of IL-1beta, TNFalpha, IL-6 and IL-8 induced by either the chaperonins or LPS
Kang et al., Cell Prolif 2008 (MAP Kinase Signaling System) : Interestingly, IL-6 activated MAPKs but EGF did not influence JAK2/STAT3 activation ; AG490 specifically inhibited IL-6 induced Erk1/2 phosphorylation without affecting IL-6 induced phosphorylation of Raf and MEK1/2
Yang et al., Microvasc Res 2009 (AIDS Dementia Complex) : Inhibitors of STAT1, mitogen activated protein kinase kinase ( MEK ) ( PD98059 ), and phosphatidyl inositol 3 kinase (PI3K) ( LY294002 ), blocked gp120 induced STAT1 activation and significantly diminished IL-8-, IL-6- , and gp120 induced monocyte adhesion and migration across in vitro BBB models
Kulas et al., J Biol Chem 1996 : While expression of CD45 was associated with a decrease in the responsiveness of early insulin receptor signaling, interleukin 6-dependent activation of mitogen activated protein kinase kinase and mitogen activated protein kinase was equivalent between CD45- and CD45+ cells
Bode et al., J Hepatol 1998 : The mitogen activated protein kinase-kinase inhibitor PD 098059 abolished phosphorylation of the extracellular signal regulated kinases-1 and -2 in response to lipopolysaccharide, irrespective of the medium osmolarity, and diminished lipopolysaccharide induced interleukin-6 mRNA expression and interleukin-6 production under normo- and hypoosmotic conditions by about 50 % ; it also resulted under hyperosmotic conditions in an about 80 % inhibition