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IL6 — ITGB1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IL6 → Complex of ITGA5-ITGB1 (increases, IL6 Activity)
  Evidence: Ligation of alpha 5 beta 1 using activating mAb JBS5 (which acts as agonist similar to FN N-terminal fragment) up-regulates the inflammatory mediators such as NO and PGE2 as well as the cytokines, IL-6 and IL-8. Furthermore, up-regulation of these proinflammatory mediators by alpha 5 beta1 integrin ligation is mediated via induction and autocrine production of IL-1 beta, because type II soluble IL-1 decoy receptor inhibits their production.

Text-mined interactions from Literome

Colantonio et al., Blood 1999 : Upregulation of integrin alpha6/beta1 and chemokine receptor CCR1 by interleukin-12 promotes the migration of human type 1 helper T cells
García de Galdeano et al., Pathobiology 2001 (Melanoma, Experimental...) : Adhesion of tumor cells to Matrigel coats increased using IL-6 , which also induced upregulation of VLA-4 expression in both sublines
Ishii et al., J Oral Pathol Med 1990 : TNF-alpha, interleukin-4 (IL-4), and transforming growth factor beta ( TGF-beta ) suppressed CD29 expression, while other cytokines, including interleukin-3 and granulocyte-macrophage colony stimulating factor, were without effect
García de Galdeano et al., Eur Cytokine Netw 1998 (Melanoma, Experimental) : Neither cell proliferation nor in vitro colony formation were affected by IL-6 ; however, the expression of CD44 and VLA-4 increased