Gene interactions and pathways from curated databases and text-mining

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BSG — IL6

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: IL6 → BSG (increases)
    Evidence: In vitro, treatment with siRNA for EMMPRIN hindered the induction of MMP-9 and MT1- MMP as well as of various cytokines such as interleukin-6 or TNF-alpha indicating a role for EMMPRIN far beyond simple MMP induction [31,32].

Text-mined interactions from Literome

Dean et al., Clin Cancer Res 2009 (Head and Neck Neoplasms) : In addition, we provide evidence that EMMPRIN suppression results in decreased interleukin 1beta (IL-1beta), IL-6 , and IL-8 cytokine production, in vitro and in vivo
Feldman et al., Microbes Infect 2011 (Bacteroidaceae Infections...) : Recombinant EMMPRIN induced the secretion of IL-6 and MMP-3 by gingival fibroblasts, a phenomenon that appears to involve mitogen activated protein kinases