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BSG — IL6
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
IL6
→
BSG
(increases)
Evidence: In vitro, treatment with siRNA for EMMPRIN hindered the induction of MMP-9 and MT1- MMP as well as of various cytokines such as interleukin-6 or TNF-alpha indicating a role for EMMPRIN far beyond simple MMP induction [31,32].
Text-mined interactions from Literome
Dean et al., Clin Cancer Res 2009
(Head and Neck Neoplasms) :
In addition, we provide evidence that
EMMPRIN suppression
results in decreased interleukin 1beta (IL-1beta),
IL-6 , and IL-8 cytokine production, in vitro and in vivo
Feldman et al., Microbes Infect 2011
(Bacteroidaceae Infections...) :
Recombinant
EMMPRIN induced the secretion of
IL-6 and MMP-3 by gingival fibroblasts, a phenomenon that appears to involve mitogen activated protein kinases