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IFNG — SMAD4

Text-mined interactions from Literome

Ulloa et al., Nature 1999 : IFN-gamma inhibits the TGF beta induced phosphorylation of Smad3 and its attendant events, namely, the association of Smad3 with Smad4 , the accumulation of Smad3 in the nucleus, and the activation of TGFbeta-responsive genes
Sumiyoshi et al., J Dermatol Sci 2003 : TGF-beta/Smad signaling inhibits IFN-gamma and TNF-alpha induced TARC ( CCL17 ) production in HaCaT cells
Thomas et al., Cancer Cell 2005 : Repression of granzyme B and interferon-gamma involves binding of TGF-beta activated Smad and ATF1 transcription factors to their promoter regions, indicating direct and selective regulation by the TGF-beta/Smad pathway
Tanaka et al., J Immunol 2008 (Encephalomyelitis, Autoimmune, Experimental) : TGF-beta mediated Smad transcriptional activity was severely inhibited in SOCS1-deficient cells in the presence of IFN-gamma ... Induction of SOCS3 can partly explain IFN-gamma mediated STAT3 suppression, while other mechanism ( s ) will be involved in IFN-gamma mediated Smad suppression