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IFNG — SETBP1
Text-mined interactions from Literome
Jahreis et al., Br J Dermatol 2000
(Dermatitis, Atopic) :
Both antigens, as well as
SEB ,
induced IL-4 and
IFN-gamma secretion in patients and controls ... However, patients with AD showed a significantly diminished
IFN-gamma production in
response to NP-tase or
SEB
Kell et al., Surgery 2000
(Burns) :
Burn injury markedly enhanced
SEB stimulated
IFN-gamma production by WT spleen cells and CD8+ T cells, while this did not occur in SEB stimulated lpr spleen cells
Izeradjene et al., Transplantation 2001
:
MMF treatment decreased tumor necrosis factor alpha,
interferon gamma , and interleukin-10 secretion
induced by
SEB
Komisar et al., Toxicol Pathol 2001
(Shock, Septic) :
All monkeys made IL-2, TNF, and
IFN-gamma in
response to
SEB
Stuyt et al., Infect Immun 2001
:
In contrast, TSST-1 induced IFN-gamma was not significantly reduced in the presence of IL-18BP, anti-IL-12 antibodies, IL-1Ra, or anti-TNFbp. SEB induced IFN-gamma was significantly inhibited only by anti-IL-12 antibodies, indicating that endogenous IL-18, IL-1, and TNF are not required for
SEB induced
IFN-gamma
Torres et al., J Immunol 2002
(MAP Kinase Signaling System) :
Inhibitors of the mitogen pathway of MAP kinase blocked
SEB induced proliferation and
IFN-gamma production, while an inhibitor of the p38 stress pathway had no effect
Smart et al., Clin Exp Allergy 2002
(Hypersensitivity) :
Symptomatic atopic children had reduced
SEB induced
IFN-gamma and increased SEB induced IL-4 and IL-5 as compared with non-atopic controls ... In contrast,
SEB induced
IFN-gamma , IL-4 and IL-5 production in asymptomatic atopics was not significantly different from the non-atopic control subjects
Hisano et al., Arch Dermatol Res 2003
(Dermatitis, Atopic) :
Polyphenon inhibited the lethal toxicity of SEB and the
SEB induced production of TNF-alpha,
IFN-gamma and IL-4 following its intraperitoneal administration to BALB/c mice ... Furthermore, EGCg inhibited
SEB induced TNF-alpha and
IFN- gamma production and IL-2, IFN-gamma, IL-10 and IL-12 p40 mRNA expression in human PBMCs from normal donors in a dose dependent manner
Rowe et al., J Allergy Clin Immunol 2004
(Genetic Predisposition to Disease...) :
In contrast, sensitization was strongly associated with polyclonal
IFN-gamma responses to both PHA ( P=.002 ) and
SEB ( P=.005 ), and also with SEB induced IL-5 ( P =.05 ), IL-10 ( P =.02 ), and IL-13 ( P =.01 )
Kruse et al., J Interferon Res 1992
:
In the
presence of
SEB , cord blood cells produced interleukin-2 (IL-2) and significant amounts of
IFN-gamma
Sweeney et al., Br J Surg 2005
(Esophageal Neoplasms...) :
There was a significant increase in the production of IL-2 after surgery without a concomitant increase in
IFN-gamma or IL-10 in
response to
SEB
Watson et al., Cell Immunol 2005
:
Pretreatment or co-treatment of human PBMC or murine lymphnode cells with EGCG significantly reduced
SEB induced proliferation and IL-2,
IFNgamma , and TNFalpha production
Prescott et al., Clin Exp Allergy 2005
(Dermatitis, Atopic) :
The administration of probiotics was associated with a significant increase in T-helper type 1 ( Th1-type ) cytokine
IFN-gamma responses to PHA and
SEB at the end of the supplementation period ( week 8 : P = 0.004 and 0.046 ) as well as 8 weeks after ceasing supplementation ( week 16 : P = 0.005 and 0.021 ) relative to baseline levels of response ... The increase in
IFN-gamma responses to
SEB was directly proportional to the decrease in the severity of AD ( r = -0.445, P = 0.026 ) over the intervention period
Renckens et al., J Immunol 2006
:
Both PAI-1 ( -/- ) CD4+ and CD8+ T cells produced more
IFN-gamma upon
stimulation with
SEB
Douglas et al., Laryngoscope 2007
(Chronic Disease...) :
SEB increased the expression of
IFN-gamma , and this effect was magnified by the addition of SEB and fungal extracts together to the culture medium
Ardern-Jones et al., Proc Natl Acad Sci U S A 2007
(Dermatitis, Atopic) :
This response was mediated by two synergistic mechanisms : first,
SEB induced
IFN-gamma promoted class II and intercellular adhesion molecule-1 expression by presenting keratinocytes ; and second, SEB induced IL-4 directly amplified allergen-specific CD4 ( + ) T cell production of many cytokines
Kohno et al., Exp Eye Res 2009
(Autoimmune Diseases...) :
Furthermore,
SEB enhanced not only the IRBP-specific T-cell proliferative responses but also
IFN-gamma and IL-17 production
Pérez-Bosque et al., J Nutr 2010
(Inflammation...) :
In both tissues, SDP prevented the increase in
IFNgamma , IL-6, and LTB ( 4 )
induced by
SEB ( P < 0.05 )
Dauby et al., PLoS Negl Trop Dis 2009
(Chagas Disease...) :
This was associated with a type 1-biased immune environment at birth, since cells of M+B+ newborns produced higher
IFN-gamma levels in
response to
SEB
Krakauer et al., Mediators Inflamm 2010
(Hypothermia...) :
SEB induced low levels of TNFalpha, IL-1,
IFNgamma , MIP-2, and LPS synergized with SEB in the expression of these cytokines and that of IL-6 and MCP-1
Lee et al., Immunology 1990
:
Staphylococcal enterotoxin B (SEB) induced the production of human
interferon-gamma ( hIFN-gamma ) in peripheral blood mononuclear cells ( PBMC )
Yokomizo et al., J Vet Med Sci 1995
:
SEA,
SEB , SEC and TSST-1, all
induced the in vitro release of interleukin-2,
interferon gamma and tumor necrosis factor alpha in a dose dependent manner
Florquin et al., J Exp Med 1994
(Shock, Septic) :
In vitro experiments indicated that NO synthase (NOS) inhibition by N-nitro-L-arginine methyl ester ( L-NAME ) enhanced
IFN-gamma and TNF production by splenocytes in
response to
SEB
D'Orazio et al., J Immunol 1995
:
In addition,
SEB induced
IFN-gamma secretion from sorted CD56+ cells
Nakata et al., J Immunol 1995
:
When rhIL-1 was administered within 24 h after SEB inoculation, the cytokine interfered with tolerance induction ; V beta 8+CD4 T cells from mice that had been treated with both SEB and IL-1 proliferated in
response to
SEB and produced IL-2, IL-4, and
IFN-gamma upon TCR/CD28 cross linking
Cardell et al., Eur J Immunol 1993
:
We further demonstrate that IL-4 and IL-10 or
IFN-gamma production was selectively
induced in resting, high-density CD4+ T cells during primary stimulation, by
SEB + IL-4 or SEB
König et al., Int Arch Allergy Immunol 1995
(Dermatitis, Atopic) :
In contrast to normal donors T cells from donors with AD predominantly express mRNA for IL-4, IL-5, and only diminished levels for
IFN-gamma and IL-12 upon
stimulation with
SEB and SEA
Nagaki et al., Gastroenterology 1994
(Shock) :
SEB induced the production of TNF-alpha and
IFN-gamma in a dose dependent manner from splenic mononuclear cells in vitro ... The results show that SEB contributes to lethal shock associated with severe hepatic injury in GalN sensitized mice and suggest that TNF-alpha and
IFN-gamma produced in
response to
SEB may be mediators of the lethal toxicity and hepatotoxicity of SEB
Kotb et al., Infect Immun 1993
:
SEB was a 2- to 14-fold-more-potent
inducer of
IFN-gamma production
Maeurer et al., Nat Immun 1995
(Colonic Neoplasms...) :
In marked contrast,
SEB induced T cell proliferation and
IFN-gamma release in the absence of stimulator cells ...
SEB induced secretion of
IFN-gamma by gamma delta T cells which could be augmented if stimulator cells ( HCT116 ) were also added to gamma delta T cells ... The
induction of
IFN-gamma release and proliferative gamma delta + T cell responses by
SEB suggests a pivotal role for intestinal gamma delta T cells in mediating immune responses against bacteria and bacterial products, or potentially in anti-tumor directed immunity
Radons et al., Diabetes 1997
(Diabetes Mellitus, Type 2) :
In addition, only NOD and NOR spleen cells were low producers of the T-helper 1 ( Th1 ) cytokine
IFN-gamma in
response to
SEB
Tiegs et al., Acta Gastroenterol Belg 1997
(Autoimmune Diseases...) :
Anti-CD3 mAb as well as
SEB or Con A
induced the release of systemic tumor necrosis factor (TNF),
interferon gamma (IFN gamma) , and various other cytokines
Di Stefano et al., J Pept Res 1998
:
We synthesized eight peptides with alanine replacement of all residues in the SEB sequence 131-138 and tested them for the capacity to inhibit both
SEB induced proliferation of human lymphomonocytes and the production of tumor necrosis factor alpha and
interferon gamma