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IFNG — IL17D

Text-mined interactions from Literome

Takeda et al., J Immunol 2003 : Although IL-27 did not directly induce IFN-gamma production by wild-type CD4 ( + ) T cells, IL-12 dependent IFN-gamma production was augmented by IL-27 stimulation in wild-type naive CD4 ( + ) T cells but was impaired in WSX-1-deficient naive CD4 ( + ) T cells
Hibbert et al., J Interferon Cytokine Res 2003 : Interleukin-27 (IL-27) supports proliferation of naive CD4 ( + ) T cells and enhances interferon-gamma (IFN-gamma) production by activated T cells and natural killer ( NK ) cells
Lucas et al., Proc Natl Acad Sci U S A 2003 : Similarly, IL-27 induces T-bet expression in primary natural killer cells, but this does not result in an increase of IFN gamma production or cytotoxic activity
Kamiya et al., J Immunol 2004 : In contrast, IL-27 hardly induced T-bet and subsequent IL-12Rbeta2 expression, and synergistic IFN-gamma production by IL-27 and IL-12 was impaired in STAT1-deficient naive CD4+ T cells
Goldberg et al., J Immunol 2004 (Disease Progression...) : We show in this study that IL-27 is involved not only in the polarization of naive T cells undergoing Ag-specific T cell activation, but also in promoting the proliferation and IFN-gamma production by polarized T cells, including the long term Th1 line that has been previously selected against the target encephalitogenic determinant
Sonobe et al., Brain Res 2005 : We show for the first time that murine microglia produce IL-27 in response to lipopolysaccharide (LPS) and/or interferon-gamma
Morishima et al., J Immunol 2005 (Colonic Neoplasms) : IL-27 induced synergistic IFN-gamma production with IL-12 and proliferation of naive CD8+ T cells
Rowland et al., Infect Immun 2006 (Glanders) : The effects of IL-18, IL-27 , and IL-12 on stimulation of the rapid IFN-gamma production were investigated in vitro by analyzing IFN-gamma production in the presence of heat killed B. mallei ... IL-12 was essential for IFN-gamma production in vitro ; IL-18 was also involved in induction of IFN-gamma , but IL-27 was not required for IFN-gamma production in response to heat killed B. mallei
Cao et al., J Immunol 2008 (Arthritis, Experimental...) : This activity has been called into question based on evidence in infectious disease and autoimmune models in which IL-27 is not absolutely required for the generation of IFN-gamma , and IL-27 plays a regulatory role in controlling inflammation
Frasca et al., J Immunol 2008 : IFN-gamma itself induced IL-27p28 expression and survival but did not promote relevant CCR7-driven migration or activated Th-1 cell recruitment capacity in MDDC ... Administered in association with classical maturation stimuli such as CD40 or TLR-4 stimulation, IFN-gamma up-regulated IL-27 and IL-12 production, CCR7-driven migration, and activated Th-1 cell recruitment, whereas it decreased IL-10 production and STAT3 phosphorylation
Villarino et al., Int Immunol 2008 (Chronic Disease...) : In both models of intestinal inflammation, improved clinical outcome was associated with reduced inflammation and profound attenuation of T ( h ) 1 responses and, consistent with these in vivo findings, we confirmed that during in vitro differentiation, IL-27 directly promotes CD4 ( + ) T cell IFN-gamma production through effects on Tbet, a key T ( h ) 1 transcription factor
Liu et al., Scand J Immunol 2008 (Esophageal Neoplasms...) : These data collectively suggest that the IL-27 mediated antitumour effects produced in a mature T cell-defective condition were attributable to enhanced interferon-gamma production and natural killer activities
Shimozato et al., Immunology 2009 (Neoplasms) : The secreted mp28 prevented the IL-27 mediated signal transduction and activator of transcription 1 phosphorylation and subsequently inhibited the IL-27 mediated intercellular adhesion molecule-1 induction and interferon-gamma production in CD4 ( + ) T cells
Murugaiyan et al., Proc Natl Acad Sci U S A 2010 (Encephalomyelitis, Autoimmune, Experimental) : Here, we show that IFN-gamma induces IL-27 while inhibiting OPN expression in DCs both in vitro and in vivo and that engagement of IFN-gammaR expressed by DCs leads to suppression of IL-17 production while inducing IL-10 from T cells
Chen et al., Zhongguo Dang Dai Er Ke Za Zhi 2010 (Asthma) : [ Interleukin-27 affects IFN-gamma and IL-4 activities in children with asthma ]