Gene interactions and pathways from curated databases and text-mining

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EGF — PDCD4

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: PDCD4 → EGF (increases) Olsen et al., Cell 2006*
    Evidence: We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database

Text-mined interactions from Literome

Tikhomirov et al., J Cell Sci 2005 : Bax activation and translocation to mitochondria mediate EGF induced programmed cell death ... Previous studies indicate that cells expressing elevated levels of the EGFR and ErbB-2 undergo programmed cell death in response to EGF or other EGFR ligands
Yao et al., Acta Biochim Biophys Sin (Shanghai) 2010 : EGF induced programmed cell death usually coincided with a decline in mitochondrial EGFR