Miyamoto et al., Cancer Cell 2003
(Carcinoma, Ductal...) :
Notch is also activated as a direct consequence of EGF receptor activation in exocrine pancreas and is required for TGF alpha induced changes in epithelial differentiation
Yu et al., Dev Biol 2009
:
Nonetheless, the overall logic is similar in the VPCs and the HCG : EGF and/or WNT induce a 1 degree lineage, and LIN-12/NOTCH induces a 2 degrees lineage
Karp et al., Proc Natl Acad Sci U S A 2013
:
When hermaphrodites are grown under favorable conditions, the EGF mediated `` inductive '' signal and the LIN-12/Notch mediated `` lateral '' signal confer a precise spatial pattern of distinct vulval cell fates in the third larval stage, a day after hatching