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CTNNB1 — PSEN1

Pathways - manually collected, often from reviews:

• KEGG Wnt signaling pathway: PSEN1 → CTNNB1 (protein-protein, activation)
• NCI Pathway Database Presenilin action in Notch and Wnt signaling: beta catenin/beta TrCP1 complex (CTNNB1-FBXW11) → Gamma Secretase complex (PSEN1-NCSTN-APH1A-PSENEN-APH1B) (modification, collaborate)
  Soriano et al., J Cell Biol 2001
  Evidence: assay, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: PSEN1 — CTNNB1 Yu et al., J Biol Chem 1998*
• IRef Bind Interaction: CTNNB1 — PSEN1 Levesque et al., J Neurochem 1999*
• IRef Bind_translation Interaction: PSEN1 — CTNNB1 (coimmunoprecipitation) Yu et al., J Biol Chem 1998*
• IRef Bind_translation Interaction: CTNNB1 — PSEN1 (unspecified method) Levesque et al., J Neurochem 1999*
• IRef Biogrid Interaction: CTNNB1 — PSEN1 (physical association, affinity chromatography technology) Serban et al., J Biol Chem 2005*
• IRef Biogrid Interaction: CTNNB1 — PSEN1 (physical association, affinity chromatography technology) Tesco et al., J Biol Chem 1998*
• IRef Biogrid Interaction: CTNNB1 — PSEN1 (physical association, affinity chromatography technology) Prager et al., J Biol Chem 2007*
• IRef Biogrid Interaction: CTNNB1 — PSEN1 (physical association, affinity chromatography technology) Kang et al., J Neurosci 1999*
• IRef Biogrid Interaction: CTNNB1 — PSEN1 (physical association, affinity chromatography technology) Murayama et al., FEBS Lett 1998*
• IRef Biogrid Interaction: CTNNB1 — PSEN1 (direct interaction, pull down) Prager et al., J Biol Chem 2007*
• IRef Hprd Interaction: CTNNB1 — PSEN1 (in vivo) Stahl et al., J Biol Chem 1999*, Kang et al., J Neurosci 1999*, Kesavapany et al., Eur J Neurosci 2001*, Baki et al., Proc Natl Acad Sci U S A 2001*, Xia et al., Proc Natl Acad Sci U S A 2002*, Raurell et al., J Biol Chem 2006*, Murayama et al., FEBS Lett 1998*
• IRef Hprd Interaction: CTNNB1 — PSEN1 (in vitro) Stahl et al., J Biol Chem 1999*, Kang et al., J Neurosci 1999*, Kesavapany et al., Eur J Neurosci 2001*, Baki et al., Proc Natl Acad Sci U S A 2001*, Xia et al., Proc Natl Acad Sci U S A 2002*, Raurell et al., J Biol Chem 2006*, Murayama et al., FEBS Lett 1998*
• IRef Innatedb Interaction: Complex of CDH1-PSEN1-CTNNB1 (unknown, -) Serban et al., J Biol Chem 2005*
• IRef Intact Interaction: Complex of 13 proteins (association, anti bait coimmunoprecipitation) Raurell et al., J Biol Chem 2006*
• IRef Intact Interaction: PSEN1 — CTNNB1 (physical association, anti bait coimmunoprecipitation) Raurell et al., J Biol Chem 2006*
• IRef Intact Interaction: PSEN1 — CTNNB1 (physical association, coimmunoprecipitation) Raurell et al., J Biol Chem 2006*
• IRef Mppi Interaction: PSEN1 — CTNNB1 (coimmunoprecipitation) Levesque et al., J Neurochem 1999*
• IRef Ophid Interaction: PSEN1 — CTNNB1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: PSEN1 — CTNNB1 (aggregation, confirmational text mining) Xia et al., Proc Natl Acad Sci U S A 2002*

Text-mined interactions from Literome

Kang et al., J Neurosci 1999 (Adenomatous Polyposis Coli...) : Inducible overexpression of PS1 led to increased association of beta-catenin with glycogen synthase kinase-3beta ( GSK-3beta ), a negative regulator of beta-catenin, and accelerated the turnover of endogenous beta-catenin ... In support of this finding, the beta-catenin half-life was dramatically longer in fibroblasts deficient in PS1, and this phenotype was completely rescued by replacement of PS1, demonstrating that PS1 normally stimulates the degradation of beta-catenin
Weihl et al., Neuroreport 1999 (Alzheimer Disease) : In the present study, we confirm that PS1-WT, as well as mutant PS1, associates with beta-catenin, and that mutant PS1 expression decreases the stability and/or enhances the degradation of beta-catenin
Soriano et al., J Cell Biol 2001 (Alzheimer Disease) : Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing ... PS1 deficiency results in accumulation of cytosolic beta-catenin , leading to a beta-catenin/LEF dependent increase in cyclin D1 transcription and accelerated entry into the S phase of the cell cycle
Kawamura et al., Eur J Biochem 2001 : The expression of mutated PS1 inhibited the Wnt-3A induced accumulation of beta-catenin
Palacino et al., J Biol Chem 2001 (Alzheimer Disease) : To examine whether regulation of beta-catenin by PS1 requires phosphorylation by glycogen synthase kinase 3beta ( GSK 3beta ), we examined whether inhibiting GSK 3beta activity overcomes the inhibition of beta-catenin transcription induced by mutant PS1 constructs ... Neither treatment overcame PS1 mediated inhibition of beta-catenin signaling, suggesting that regulation of beta-catenin by PS1 was not affected by the activity of GSK 3beta ... To investigate how PS1 might regulate beta-catenin signaling, we determined whether PS1 interacts with other elements of the beta-catenin signaling cascade, such as the Tcf-4 transcription factor
Kang et al., Cell 2002 (Alzheimer Disease...) : Thus, presenilin deficiency results in increased beta-catenin stability in vitro and in vivo by disconnecting the stepwise phosphorylation of beta-catenin, both in the presence and absence of Wnt stimulation
Meredith et al., Biochem Biophys Res Commun 2002 : Gamma-secretase activity is not involved in presenilin mediated regulation of beta-catenin ... Gamma-secretase activity is not involved in presenilin mediated regulation of beta-catenin
Fluhrer et al., J Biol Chem 2004 : In addition, PS1 plays a role in beta-catenin signaling and in the regulation of apoptosis
Serban et al., J Biol Chem 2005 : Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability ... Thus, cadherins mediate both the association of PS1 and beta-catenin and the effects of PS1 on the cellular levels of beta-catenin
Raurell et al., PloS one 2008 (Alzheimer Disease) : Gamma-secretase dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity