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Pai et al., FASEB J 2003
(Colonic Neoplasms...) :
Here we provide evidence that PGE2 transactivates c-Met-R ( contingent upon functional EGFR ), increases tyrosine phosphorylation and nuclear accumulation of
beta-catenin , and
induces urokinase-type
plasminogen activator receptor ( uPAR ) mRNA expression
Pai et al., Mol Biol Cell 2004
(Colonic Neoplasms...) :
Our results show that low concentrations of DCA ( 5 and 50 microM ) significantly increase tyrosine phosphorylation of
beta-catenin ,
induce urokinase-type
plasminogen activator, uPAR, and cyclin D1 expression and enhance colon cancer cell proliferation and invasiveness