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CSN3 — KITLG

Text-mined interactions from Literome

Yang et al., Curr Biol 2002 : We conclude that CSN inhibits SCF ubiquitin ligase activity in targeting p27 proteolysis and negatively regulates cell cycle at the G1 phase by promoting deneddylation of Cul1
Stuttmann et al., J Biol Chem 2009 : These results are consistent with CSN dependent protection of Arabidopsis CRLs from autocatalytic degradation, as observed in other eukaryotes, and provide evidence for antagonist roles of the CSN and 26S proteasome in modulating accumulation of the plant CRL SCF ( TIR1 )
Enchev et al., Cell reports 2012 : Indeed, CSN binding prevents SCF interactions with E2 enzymes and a ubiquitination substrate, and it inhibits SCF catalyzed ubiquitin chain formation independent of deneddylation