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CD4 — TNFSF9
Text-mined interactions from Literome
Gramaglia et al., Eur J Immunol 2000
:
Blocking studies with activated B cells presenting antigen showed that 4-1BB participates in promoting IL-2 production by resting CD4 cells, confirming that
4-1BBL can
play a role in antigen-specific
CD4 T cell responses
Blazar et al., J Immunol 2001
(Graft vs Host Disease...) :
By quantifying graft-vs-host disease alloresponses in vivo, we demonstrate that both
CD4 ( + ) and CD8 ( + ) T cell mediated alloresponses are
regulated by
4-1BB/4-1BB ligand interactions to approximately the same extent
Wen et al., J Immunol 2002
:
However, murine
4-1BBL can
stimulate both
CD4 and CD8 T cells ... To further understand the role of 4-1BBL in human T cell responses, we compared human
CD4 and CD8 T cell
responses to transfected human
4-1BBL plus TCR mediated stimulation
Dawicki et al., Eur J Immunol 2004
:
To clarify the
role of
4-1BB/4-1BBL in
CD4+ versus CD8+ T cell responses in vivo, we compared CD4 ( OT-II ) and CD8 ( OT-I ) TCR transgenic T cells responding to the same antigen in an in vivo adoptive transfer model in 4-1BBL ( +/+ ) versus 4-1BBL ( -/- ) mice