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IL12B — SAA1
Text-mined interactions from Literome
He et al., J Immunol 2006
:
In peripheral blood monocytes and the THP-1 monocytic cell line,
SAA induces the expression of
IL-12p40 , a subunit shared by IL-12 and IL-23 ...
SAA stimulated expression of
IL-12p40 was rapid ( < or = 4 h ), sustainable ( > or = 20 h ), potent ( up to 3380 pg/ml/10 ( 6 ) cells in 24 h ), and insensitive to polymyxin B treatment ... The
SAA stimulated
IL-12p40 secretion required de novo protein synthesis and was accompanied by activation of the transcription factors NF-kappaB and C/EBP ... Interestingly, the
SAA induced
IL-12p40 production was accompanied by a sustained expression of IL-23p19, but not IL-12p35, resulting in preferential secretion of IL-23, but not IL-12
Migita et al., Clin Exp Immunol 2010
(Arthritis, Rheumatoid) :
These results indicate that
SAA is a significant
inducer of
IL-23 and IL-1ß in RA synoviocytes and potentially activates the IL-23/IL-17 pathway in the RA synovium