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KAT8 — TP53

Pathways - manually collected, often from reviews:

• NCI Pathway Database p53 pathway: hMOF (KAT8) → p53 (tetramer) complex (TP53) (modification, activates)
  Sykes et al., Mol Cell 2006, Mellert et al., Cell cycle (Georgetown, Tex.) 2007*
  Evidence: mutant phenotype, assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: KAT8 — TP53 (direct interaction, enzymatic study) Sykes et al., Mol Cell 2006
• IRef Biogrid Interaction: KAT8 — TP53 (direct interaction, enzymatic study) Li et al., Mol Cell 2009*
• IRef Biogrid Interaction: KAT8 — TP53 (direct interaction, pull down) Dou et al., Cell 2005
• IRef Intact Interaction: KAT8 — TP53 (physical association, anti tag coimmunoprecipitation) Tyteca et al., EMBO J 2006*
• IRef Intact Interaction: Complex of KAT8-WDR5-MEN1-RBBP5-KMT2A-TP53 (association, pull down) Dou et al., Cell 2005

Text-mined interactions from Literome

Li et al., Mol Cell 2009 : We further demonstrate that MOF-MSL1v1 is specifically required for optimal transcription activation of p53 target genes both in vitro and in vivo
Zhang et al., International journal of clinical and experimental pathology 2013 (Lung Neoplasms) : Moreover, KAT8 inhibition led to p53 induction and subsequently reduced bcl-2 expression