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SFTPA1 — TLR2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TLR2 → SFTPA1 (increases, SFTPA1 Activity)
  Evidence: endogenous ligands are being reported as candidate stimulators of TLRs, in particular of TLR2 and TLR4. These include heat shock proteins (HSP60, HSP70, endoplasmin, HSPB8 and ?-crystallin A chain)7–13, high mobility group box 1 (HMGB1)14,15, uric acid crystals16,17, surfactant protein A18, and various products of the extracellular matrix such as fibronectin19, heparan sulphate20, biglycan21, fibrinogen22, oligosaccharides of hyaluronan23 and hyaluronan breakdown fragments24–26.
• NCI Pathway Database Endogenous TLR signaling: SFTPA1 (SFTPA1) → TLR2 (TLR2) (modification, collaborate) Murakami et al., J Biol Chem 2002*, Sato et al., J Immunol 2003*
  Evidence: physical interaction
• NCI Pathway Database Endogenous TLR signaling: SFTPA1 (SFTPA1) → SFTPA1/TLR2/TLR1 complex (TLR2-TLR1-SFTPA1) (modification, collaborate)
  Murakami et al., J Biol Chem 2002*, Sato et al., J Immunol 2003*
  Evidence: physical interaction
• NCI Pathway Database Endogenous TLR signaling: TLR1 (TLR1) → SFTPA1/TLR2/TLR1 complex (TLR2-TLR1-SFTPA1) (modification, collaborate)
  Murakami et al., J Biol Chem 2002*, Sato et al., J Immunol 2003*
  Evidence: physical interaction
• NCI Pathway Database Endogenous TLR signaling: TLR2 (TLR2) → SFTPA1/TLR2/TLR1 complex (TLR2-TLR1-SFTPA1) (modification, collaborate)
  Murakami et al., J Biol Chem 2002*, Sato et al., J Immunol 2003*
  Evidence: physical interaction
• WikiPathways Regulation of toll-like receptor signaling pathway: SFTPA1 → TLR2 (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: TLR2 — SFTPA1 (in vitro) Murakami et al., J Biol Chem 2002*

Text-mined interactions from Literome

Sato et al., J Immunol 2003 : Direct binding of Toll-like receptor 2 to zymosan, and zymosan induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A
Henning et al., J Immunol 2008 : Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages