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CXCL10 — TLR2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CXCL10 → TLR2 (increases, TLR2 Translocation, CXCL10 Activity)
  Evidence: stimulation of SAEC with the TLR5 ligand flagellin resulted in a less pronounced secretion of the IFN-inducible chemokine IP-10, but induced the secretion of similar levels of MIP3alpha, MIP3beta and GRO-alpha (Fig. 2A). MALP-2, a specific ligand for TLR2/TLR6 heterodimers, increased the secretion of IP-10, MIP-3alpha and GRO-alpha The TLR2 ligand zymosan induced an elevated secretion of GRO-alpha (Fig. 2A).

Text-mined interactions from Literome

Aravalli et al., J Immunol 2005 (Herpes Simplex) : CXCL9 and CXCL10 were also induced by HSV, but their production was not dependent upon TLR2 signaling
Hung et al., Nephrol Dial Transplant 2006 : The LMPS enhanced the secretion of CCL2/MCP-1 and CXCL8/interleukin-8 (CXCL8/IL-8) in TLR-defective human embryonic kidney (HEK) 293 cells only when transfected with a TLR2 expressing plasmid
Qian et al., Blood 2007 : Blockade of IFN-alpha/beta inhibits IP-10 production by TLR agonist activated regulatory DCs
Bsibsi et al., Glia 2007 : Moreover, the CD14 triggered TLR2 mediated response in astrocytes lead to the production of CXCL8 , IL-6, and IL12p40, whereas typical TLR induced pro-inflammatory cytokines, like TNF-alpha and IL-1beta, were not produced at detectable levels
Méndez-Samperio et al., Arch Med Res 2008 : Moreover, it is important to note that the levels of CXCL8 secretion and mRNA were markedly ( 94 % ) reduced by functional blocking of both TLR2 and TLR4
Wang et al., Blood 2008 : We and others have reported that Toll-like receptor ( TLR ) proteins are present on human neutrophils and that granulocyte-macrophage colony stimulating factor ( GM-CSF ) treatment enhances IL-8 ( CXCL8 ) secretion in response to stimulation with TLR ligands
Lee et al., J Clin Immunol 2009 : These results indicate that TLR2-ROS signaling plays a crucial role in the 30-kDa Ag-mediated expression of CXCL8 and CCL2 in human monocytes
Lee et al., Cell Microbiol 2009 : In addition, TLR2 , Dectin-1 and, to an extent, TLR4 are essential for the MU-mediated expression of CXCL8 , CCL2 and LL-37 in keratinocytes ... In addition, TLR2 , Dectin-1 and, to an extent, TLR4 are essential for the MU-mediated expression of CXCL8 , CCL2 and LL-37 in keratinocytes
Farges et al., Immunobiology 2011 : We found that odontoblasts produce the pro-inflammatory cytokines interleukin (IL)-6 and CXCL8 , as well as the immunosuppressive cytokine IL-10 in response to TLR2 agonists
Kwissa et al., Blood 2012 : Furthermore, all TLR-Ls induced rapid ( 3-8 hours ) expansion of CD14 ( + ) monocytes, but only TLR7/8-L and TLR9-L mobilized the CD14 ( + ) CD16 ( + ) and CD14 ( dim ) CD16 ( ++ ) monocytes, and only TLR7/8-L and TLR9-L induced activation of myeloid dendritic cells ( mDCs ) and plasmacytoid DCs ( pDCs ), production of IP-10 and type-I IFN, and expression of type-I IFN related and chemokine genes in the blood
Abe et al., J Virol 2012 : In this study, we examined the role of the Toll-like receptor ( TLR ) pathway on IP-10 production in cells replicating HCV ... Among the CXC chemokines, the expression of IP-10 was specifically increased in cells replicating HCV upon stimulation with conventional TLR2 ligands ... The enhancement of IP-10 production upon stimulation with TLR2 ligands in cells replicating HCV induced CD44 expression ... In the present study, IP-10 production upon HA stimulation was dependent on the expression of TLR2 and CD44, and a direct association between TLR2 and CD44 was observed
Oarada et al., J Nutr Biochem 2013 (Inflammation) : TLR2 deficiency significantly attenuated the refeeding induced increase in the liver expression of Cxcl10 , Cxcl1, Icam-1 and A20
Sharma et al., J Leukoc Biol 2013 : Our findings reveal a previously unrecognized role for S1P in regulating TLR induced CXCL8 secretion from human T cells