Coutts et al., Immunol Cell Biol 1995
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The recent discovery of the involvement of heparan sulfate proteoglycans (HSPG) in the activation of fibroblast growth factor receptors ( FGFR ) has led to an intensification of study of this field ... It appears that the HSPG act as low affinity receptors to which the fibroblast growth factors ( FGF ) must bind in order to successfully activate the high affinity FGFR Qing et al., Nat Med 1999
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We demonstrate here that cell surface expression of HSPG alone is insufficient for AAV infection, and that AAV also requires human fibroblast growth factor receptor 1 ( FGFR1 ) as a co-receptor for successful viral entry into the host cell