◀ Back to RELA

LTA — RELA

Text-mined interactions from Literome

Schwandner et al., J Biol Chem 1999 : Like LPS, sPGN and LTA bind to the glycosylphosphatidylinositol anchored membrane protein CD14 and induce activation of the transcription factor NF-kappaB in host cells like macrophages ... We show that whole Gram positive bacteria, sPGN and LTA induce the activation of NF-kappaB in HEK293 cells expressing TLR2 but not in cells expressing TLR1 or TLR4 ... The sPGN- and LTA induced NF-kappaB activation was not inhibited by polymyxin B, an antibiotic that binds and neutralizes LPS
Müller et al., J Biol Chem 2003 : Lymphotoxin beta receptor induces sequential activation of distinct NF-kappa B factors via separate signaling pathways ... Lymphotoxin beta receptor (LTbetaR) induced activation of NF-kappaB in mouse embryo fibroblasts was mediated by the classical pathway and by an alternative or second pathway
Matsuguchi et al., Clin Diagn Lab Immunol 2003 : Furthermore, in HEK293T cells transected with a combination of CD14 and Toll-like receptor 2 (TLR2), NF-kappaB was activated in response to Lactobacillus LTA
Iwahashi et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid) : NF-kappaB activation in adhered monocytes was induced by LTA , but this NF-kappaB activity was not augmented by anti-FcgammaRIII antibody stimulation
Kao et al., Immunology 2005 : The LTA induced formation of an NF-kappaB-specific DNA-protein complex in the nucleus was inhibited by wortmannin, LY 294002, genistein, tyrphostin AG126, and SB 203580
Paik et al., Lab Invest 2006 (Fibrosis...) : TNF-alpha and IL-1beta significantly upregulated the expression of TLR2 mRNA and protein in HSCs. PGN and LTA induced NF-kappaB activation and stimulated production of IL-8 in HSCs. Pretreatment with TNF-alpha or IL-1beta augmented NF-kappaB activation and IL-8 production in response to PGN or LTA ... Both PGN- and LTA induced NF-kappaB activation and IL-8 secretion were completely inhibited by anti-TLR2 blocking antibody ( T2.5 )
Fabisiak et al., Am J Physiol Lung Cell Mol Physiol 2006 (Lung Diseases...) : Exposure to M. fermentans or MALP-2 did not enhance nuclear localization, DNA binding, or transcriptional activity of NF-kappaB and did not modulate early NF-kappaB activation in response to TNF-beta
Ryu et al., World J Gastroenterol 2006 (Hepatitis B) : During the initial state of HBV infection, hepatocytes facilitate the activation of NF-kappaB through up regulation of LT-alpha , TRAF2, and NIK
Hohmann et al., Mol Cell Biol 1991 (Leukemia) : No correlation exists in HL60 cells between NF-kappa B activation by tumor necrosis factor ( TNF alpha ) and TNF beta and intracellular levels of cyclic AMP
Jiao et al., Cytokine 2008 (Respiratory Distress Syndrome, Adult...) : Furthermore, ApoA-I treatment could diminish LTA mediated NFkappaB nuclear translocation in macrophages
Vallabhapurapu et al., Eur J Immunol 2008 : NF-kappaB also regulates TCR induced expression of LT-alpha and LT-beta within NKT cells
Oliver et al., Antioxid Redox Signal 2009 (Anoxia) : Sustained hypoxia enhanced basal and LTalpha1beta2 induced NF-kappaB activity in a manner that was dependent upon the canonical but not the noncanonical signaling pathway ... Knockdown of the p65 subunit of the canonical NF-kappaB pathway was sufficient to abolish the effects of hypoxia on LTalpha1beta2 induced NF-kappaB activity
Lee et al., Am J Pathol 2010 (Inflammation) : LTA stimulated NF-kappaB translocation or cPLA(2) phosphorylation was attenuated by pretreatment with LY294002, SB202190, U0126, or SP600125
Messer et al., Cytokine 1990 : The high homology of the well characterized H-2Kb enhancer sequence with the TNF-beta site with regard to sequence and factor binding strongly supports a physiological role for NF-kappa B in the inducible expression of the TNF-beta gene ... Our observation that the TNF-beta protein can rapidly induce the DNA binding activity of NF-kappa B in Jurkat T cells and transiently increase TNF-beta mRNA levels suggests that NF-kappa B can mediate a positive autoregulation of TNF-beta synthesis
Hohmann et al., J Biol Chem 1990 : TNF-alpha and TNF-beta activate the transcription factor NF-kappa B in HL60 and HEp2 cells ... Maximal activation of NF-kappa B required binding of TNF-alpha or TNF-beta to 20-25 % of the total number of TNF receptors and was achieved within minutes after the addition of TNF-alpha to HL60 cells ... Both TNF-alpha and TNF-beta activate NF-kappa B at 5-10-fold lower concentrations in HL60 cells compared with HEp2 cells, and this correlates well with their different affinities for binding to these cells
Mackay et al., J Biol Chem 1996 : Tumor necrosis factor alpha (TNFalpha) and lymphotoxin alpha ( LTalpha, originally TNFbeta ) are potent nuclear factor kappaB (NFkappaB) activators in various cell types
Chen et al., J Virol 1997 : Given the known roles of LT-betaR/LT-alpha1,beta2 receptor-ligand interactions in the normal development of peripheral lymphoid organs and in triggering cytolytic activity and NF-kappaB activation in certain cell types, our finding implies that the HCV core protein may aggravate these biological functions of LT-betaR, resulting in pathogenesis in HCV infected cells
You et al., J Virol 1999 : As demonstrated by the electrophoretic mobility shift assay, the expression of HCV core protein prolonged or enhanced the TNF-alpha or LT-alpha1beta2 induced NF-kappaB DNA binding activity in HuH-7 and HeLa cells