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JAG1 — RELA

Text-mined interactions from Literome

Bash et al., EMBO J 1999 : Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1 , a ligand for Notch receptors ... Both c-Rel and RelA induced jagged1 gene expression, whereas a mutant defective for transactivation did not ... Consistent with its Rel/NF-kappaB dependent induction , Jagged1 was found to be highly expressed in splenic B cells where c-Rel is expressed constitutively
Nickoloff et al., Cell Death Differ 2002 : Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma
Johnston et al., Gene 2009 : These results indicate that canonical NFkappaB signaling is required for TNF induction of the notch ligand jagged-1 in EC
Wang et al., J Cell Biochem 2010 (Neoplasm Invasiveness...) : Consistent with these results, we found that the down-regulation of Notch-1 or Jagged-1 led to decreased expression and the activity of NF-kappaB downstream genes such as MMP-9, VEGF, and uPA, contributing to the inhibition of cell migration and invasion