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BCR — RELA
Text-mined interactions from Literome
Petro et al., J Exp Med 2000
(Agammaglobulinemia...) :
BCR stimulation
leads to the activation of transcription factor
nuclear factor (NF)-kappaB , which in turn regulates genes controlling B cell growth ... We now demonstrate that a null mutation in btk known to cause the xid phenotype prevents
BCR induced activation of
NF-kappaB
Petro et al., J Biol Chem 2001
:
Moreover, activation of
NF-kappaB in
response to
BCR signaling is completely abolished in B cells deficient for PLC-gamma2
Bone et al., Int Immunol 2001
:
Nuclear
NF-kappaB is
induced in B cells by engagement of either the
BCR or CD40 or by stimulation with lipopolysaccharide (LPS) ... Using the specific pharmacological inhibitors of PI 3-kinase, Wortmannin and LY294002, we demonstrate that PI 3-kinase activity is vital for
BCR induced
NF-kappaB DNA binding activity
Mukhopadhyay et al., J Biol Chem 2002
:
The suppression of TNF induced NF-kappaB activation by Bcr-Abl was not restricted to MBA cells, because ectopic expression of
Bcr-Abl in human acute myeloid leukemia HL-60 cells also
blocked TNF induced
NF-kappaB activation
Korus et al., Oncogene 2002
(MAP Kinase Signaling System) :
NF-kappaB activation by
Bcr is not mediated by nuclear translocation, but rather by p38 mitogen activated protein kinase ( MAPK ) -dependent modification of the RelA/p65 transactivation domain
Su et al., Nat Immunol 2002
(Lymphoma, B-Cell) :
Here, we demonstrate that PKC-beta is specifically required for
B cell receptor (BCR) mediated
NF-kappa B activation
Saijo et al., Nat Immunol 2003
:
Impaired NF-kappaB induction was overcome by the activation of protein kinase C ( PKC ) -lambda, thus suggesting the involvement of PKC-lambda in
pre-BCR mediated SFK dependent activation of
NF-kappaB ... Our data show the existence of a functionally distinct SFK signaling module responsible for
pre-BCR mediated
NF-kappaB activation and B cell development
Kirchner et al., Exp Hematol 2003
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Mechanisms of
Bcr-Abl mediated
NF-kappaB/Rel activation ... In this paper we demonstrate
activation of
NF-kappaB/Rel by
Bcr-Abl and for the first time by v-Abl ... Furthermore, we investigated mechanisms of
NF-kappaB/Rel induction by
Bcr-Abl and v-Abl
Hanson et al., J Biol Chem 2003
:
Consistent with this, evidence has been presented that
NF kappa B activity is
required for Ras and
BCR-ABL to transform cells ... The data presented here indicate that
BCR-ABL expression in 32D myeloid cells or oncogenic Ras expression in murine fibroblasts
blocks the ability of tumor necrosis factor (TNF) to activate
NF kappa B
Ruland et al., Semin Immunol 2003
:
We focus mainly on T cell receptor ( TCR ) -mediated NF-kappaB activation and draw parallels to
B cell receptor (BCR) mediated
NF-kappaB activation where appropriate
Antony et al., Exp Cell Res 2003
(Calcium Signaling) :
Pharmacological inhibition of PKC isozymes and Ras revealed that the
BCR induced activation of
NF-kappaB requires conventional PKCbeta, whereas that of NFAT may involve non-conventional PKCdelta and Ras pathways
Middendorp et al., J Immunol 2003
:
In contrast, transgenic expression of kinase-inactive K430R-Btk completely reconstituted lambda usage in Btk-deficient mice, but the defective modulation of pre-B cell surface markers, peripheral B cell survival, and
BCR mediated
NF-kappaB induction were partially corrected
Guo et al., Curr Opin Immunol 2004
:
PKCbeta is indispensable for
B-cell antigen receptor (BCR) induced
NF-kappaB activation and B-cell survival
Lin et al., Semin Immunol 2004
(Lymphoma, B-Cell, Marginal Zone) :
Recent studies demonstrate that CARMA1, a scaffold protein, plays an essential role in mediating TCR- or
BCR induced
NF-kappaB activation by recruiting two adaptor proteins, Bcl10 and MALT1, to lipid rafts following stimulation of antigen receptors
Minguet et al., Eur J Immunol 2005
(MAP Kinase Signaling System) :
Anergic B lymphocytes exert compromised signal transduction towards the activation of
NF-kappa B in
response to
B cell antigen receptor (BCR) triggering, whereas activation of the ERK pathway appears normal
Xing et al., J Exp Med 2005
:
G5pr(-/-) B cells did not show abnormalities in the
BCR mediated
activation of Erks and
NF-kappaB , cyclin D2 induction, or Akt activation
Ahn et al., Blood 2006
:
Reduction of LIME expression by the introduction of siRNA resulted in the disruption of
BCR mediated
activation of MAPK, calcium flux, NF-AT, PI3K, and
NF-kappaB
Pappu et al., Eur J Immunol 2006
:
NF-kappaB activation through
B cell receptor (BCR) ligation is critical for B cell development, survival and antigen mediated activation of B cells ... CARD domain and MAGUK-domain containing protein-1 ( CARMA1 ), recently identified adaptor molecule, has been shown to play an essential role in
BCR induced
NF-kappaB activation
Chew et al., J Biol Chem 2007
:
The overexpression of LPXN in mouse A20 B lymphoma cells led to the suppression of
BCR induced activation of JNK, p38 MAPK, and, to a lesser extent, Akt, but not ERK and
NFkappaB , suggesting that LPXN can selectively repress BCR signaling
Rodriguez et al., Cell Signal 2007
:
Suppression of RhoB activity by dominant-inhibitory mutants, or siRNA, blocks
NF-kappaB activation by
Bcr , and TSG101, but not by TNFalpha or oncogenic Ras
Duncan et al., Mol Cancer Ther 2008
:
Additionally, we reported previously that
BCR-ABL activates the transcription factor
nuclear factor-kappaB (NF-kappaB) in a manner dependent on Ras and that inhibition of NF-kappaB by expression of a modified form of IkappaBalpha blocked BCR-ABL-driven tumor growth in a xenograft model ... These data indicate that blockage of
BCR-ABL induced
NF-kappaB activation via IkappaB kinase beta inhibition represents a potential new approach for treatment of Imatinib- or Dasatinib-resistant forms of chronic myelogenous leukemia
Schuman et al., Blood 2009
:
However, the role of TAK1 in
B-cell receptor (BCR) mediated
NF-kappaB activation and B-cell development is not clear ... Thus, TAK1 is critical for B-cell maturation and
BCR induced
NF-kappaB activation
Andrews et al., J Immunol 2009
:
T1, in contrast to follicular mature B cells, failed to express key
NF-kappaB target genes in
response to
BCR engagement and exhibited a striking defect in assembly of an active transcriptional complex at the promoter of the survival and proliferative genes A1 and c-Myc
Hoek et al., J Immunol 2009
(Lymphopenia) :
Recent studies have shown that
BCR signaling positively
regulates NF-kappaB2 , suggesting BCR regulation of BR3 signaling
Colombo et al., PloS one 2012
(Lupus Erythematosus, Systemic...) :
The effect of LAIR1 ligation by specific monoclonal antibodies, collagen or collagen producing mesenchymal stromal cells from reactive lymph nodes or bone marrow on Ig production by pokeweed mitogen and
B cell receptor (BCR) mediated
NF-kB activation was assessed by ELISA and TransAM assay
Hamdane et al., Oncogene 1997
:
Activation of p65 NF-kappaB protein by p210BCR-ABL in a myeloid cell line (
P210BCR-ABL activates p65
NF-kappaB ) ... We have analysed the
effect of
p210BCR-ABL expression on
NF-kappaB activity in DA1 cells ( an IL-3 dependent murine myeloid progenitor cell line ) ... A specific
stimulation of
NF-kappaB activity by kinase-active wild-type
p210BCR-ABL has been evidenced by transcriptional activation assays