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INSR — PRKAG2

Text-mined interactions from Literome

Raile et al., Diabetologia 2005 (Insulinoma...) : Activation of AMPK by 5-amino-imidazolecarboxamide riboside ( AICAR, 0.5 mmol/l ) suppressed Pklr expression, but strongly stimulated gene expression of Igf1r, Insr and Insrr ... Stimulation of Igf1r and Insr gene expression by the AMPK-activator AICAR might indicate involvement of AMPK in the regulation of Igf1r, Insr and Insrr expression in beta cells
Lerner et al., EMBO Rep 2009 : Hypothalamic AMPK controls the expression of the cAMP response element ( CRE ) gene, insulin receptor substrate 2 (Irs2), by regulating CRTC2 occupancy of the Irs2 promoter
Memmott et al., Cancer prevention research (Philadelphia, Pa.) 2010 (Carcinoma...) : In lung tissue, metformin did not activate AMPK but inhibited phosphorylation of insulin-like growth factor-I receptor/insulin receptor ( IGF-1R/IR ), Akt, extracellular signal regulated kinase ( ERK ), and mTOR
Chopra et al., Diabetologia 2012 (Hypoglycemia) : AMPK phosphorylates and activates the insulin receptor , providing a direct link between AMPK and the insulin signalling pathway ; this pathway promotes energy conservation and survival of muscle exposed to severe glucose deprivation
Quinn et al., Cancer prevention research (Philadelphia, Pa.) 2013 : Previously, we showed that metformin prevented tobacco carcinogen ( NNK ) -induced lung tumorigenesis in a non-diabetic mouse model, which was associated with decreased IGF-I/insulin receptor signaling but not activation of AMPK in lung tissues, as well as decreased circulating levels of IGF-I and insulin