Gene interactions and pathways from curated databases and text-mining

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PAK1 — TNF

Text-mined interactions from Literome

Kettritz et al., J Am Soc Nephrol 2002 : TNF-alpha stimulation increased association of PAK1 with Akt
Zhou et al., BMC immunology 2009 : In response to TNF-alpha or IL-1alpha, PAK1 was promptly activated, as characterized by a sequential phosphorylation, initiated at threonine-212 followed by at threonine-423 in the activation loop of the kinase, in human skin keratinocytes, dermal fibroblasts, and rat hepatic stellate cells
Park et al., Am J Physiol Lung Cell Mol Physiol 2012 : These combined data are consistent with the hypothesis that PPAR? stimulates MUC1/Muc1 expression, thereby blocking PMA/PAK induced TNF-a/IL-8 production by airway epithelial cells