Gene interactions and pathways from curated databases and text-mining

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MPO — PTGS1

Pathways - manually collected, often from reviews:

  • BioCarta eicosanoid metabolism: None → PGH2 synthase complex (PTGS1_COX2-MPO) (modification, inhibits)
  • BioCarta eicosanoid metabolism: None → PGH2 synthase complex (PTGS1_COX2-MPO) (modification, collaborate)

Text-mined interactions from Literome

Tanigawa et al., Am J Physiol Gastrointest Liver Physiol 2004 (Gastritis...) : Inhibition of both COX-1 and -2 by indomethacin or concurrent treatment with SC-560 and NS-398 resulted in a stronger increase in MPO activity and apoptosis than inhibition of either COX-1 or -2 alone
Rider et al., Journal of enzyme inhibition 1996 : Comparative effects of selective cyclooxygenase 1 and cyclooxygenase 2 inhibitors on myeloperoxidase and 3 alpha-hydroxysteroid dehydrogenase