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IRF6 — SOAT1

Text-mined interactions from Literome

Pratt et al., Shock 2000 (Colonic Neoplasms) : We infer from these data that IL-6 acts on intestinal epithelia through a Stat5 mediated transcriptional mechanism, whereas LPS does not induce gene expression through autocrine activation of enterocyte Stat signaling
Severgnini et al., Am J Physiol Lung Cell Mol Physiol 2004 (Acute Disease...) : Furthermore, IL-6 was induced by LPS in serum and in the lung with kinetics consistent with STAT3 activation, suggesting that IL-6 may be one mechanism of STAT activation by LPS ... In addition, STAT activation required reactive oxygen species, as the overexpression of catalase in mice prevented LPS mediated STAT activation in the lung
Nishiki et al., Am J Physiol Cell Physiol 2004 (MAP Kinase Signaling System) : G-CSF induced, but not IL-10 induced, STAT3 phosphorylation was attenuated in the presence of LPS
Powell et al., Clin Dev Immunol 2004 : We determined that the marked synergy between LPS and IFN-gamma on MIG mRNA expression in mouse macrophages is a result of LPS induced NF-kappaB and IFN-gamma induced STAT
Liu et al., Zhonghua Shao Shang Za Zhi 2005 : In addition, the cells were divided into normal control, LPS stimulation, JAK2 inhibition ( with AG490 treatment 2 hours before LPS stimulation ), STAT1 inhibition ( with fludarabine treatment 2 hours before LPS stimulation ) and STAT3 inhibition ( with rapamycin treatment 2 hours before LPS stimulation ) groups ... LPS could activate JAK2, STAT1 and STAT3 within 2 hours, especially the activation of STAT3 appeared more quickly, peaking at 10 minutes after LPS stimulation ( 7.47 +/- 0.56 )
Qin et al., J Immunol 2006 : Ectopic expression of SOCS-3 attenuates LPS induced STAT activation, and inhibits LPS induced CD40 gene expression, comparable to that seen by IL-10
Ichikawa et al., Endocrinology 2008 (Inflammation) : Knockdown of MKP-1 by MKP-1 small interfering RNA enhanced the LPS induced STAT1 phosphorylation, suggesting that MKP-1 acts as a negative regulator for LPS induced STAT signaling
Schaefer et al., Mol Immunol 2009 : Finally, LPS induced activity of the trimeric Stat-motif in front of the luciferase reporter was suppressed by IFNgamma
Ichikawa et al., J Ethnopharmacol 2009 (MAP Kinase Signaling System) : While American ginseng had no impact on LPS induced activation of AP-1 or NF-kappaB pathways, it dramatically inhibited LPS induced activation of STAT signaling
Liu et al., Chinese medicine 2012 : This study demonstrates that a-MG attenuates LPS mediated activation of MAPK, STAT1 , c-Fos, c-Jun and EIK-1, inhibiting TNF-a and IL-4 production in U937 cells
Lin et al., J Immunol 2012 : In contrast, 3-MA suppressed LPS induced IFN-ß production and STAT signaling
Yamaoka et al., J Immunol 1998 : Taken together, these results suggest that in addition to other transcription factors, STAT5 plays an important role in activation of monocytes by LPS , and that STAT5 is another target for IL-10 and Dex to inhibit COX-2 expression in activated monocytes
Lee et al., Biochem J 1999 : This study suggests that the effects of LPS on hepatic MT-I gene expression are mediated by IL-6 and involve the activation of STAT binding to the proximal promoter