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IRF6 — NOX1
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Brandes et al., Hypertension 1999
(Endotoxemia...) :
Expression of XO and
NAD ( P ) H oxidase ( p22phox, p67phox, and gp91phox ) were
increased by
LPS in a time dependent manner, as were protein tyrosine nitration and ONOO- formation
Melgert et al., J Hepatol 2000
(Inflammation) :
Both coupled and uncoupled Dexa showed effective inhibition of
LPS induced
NOx and TNFalpha production in precision-cut liver slices
Maekawa et al., Inflamm Res 2000
(Liver Neoplasms, Experimental) :
Moreover,
LPS- or IL-2-stimulation
increased the levels of TNF-alpha and
NOx in the supernatants of AH-130 cell and macrophage co-culture, although LPS and IL-2 did not induce TNF-alpha and NOx production by AH-130 cells incubated without macrophages
Wang et al., Chin Med J (Engl) 1999
(Intussusception) :
Furthermore,
LPS increased total NOS activity,
NOx production and cGMP levels in plasma or in colic smooth muscle tissues
Piganelli et al., Diabetes 2002
(Diabetes Mellitus, Experimental...) :
In addition, pretreatment of lipopolysaccharide (LPS) stimulated peritoneal macrophages with SOD mimic inhibited the
LPS dependent increase in TNF-alpha as well as the
NADPH oxidase dependent release of superoxide
Mailman et al., Dig Dis Sci 2002
:
At 50 microM, luminal NOLARG attenuated the
LPS induced
NOx secretion and increased blood pressure ... The
LPS induced luminal
NOx secretion was blocked by 500 microM intraluminal AMGU and NOLARG ... Luminal 500 microM NOLARG prevented the
LPS induced increase in plasma [
NOx ] and the decrease in leukocytes, but AMGU did not
Romeo et al., J Pediatr Surg 2003
:
LPS stimulation produced a strong
increase in
NOx production in laparotomy MPhis and control MPhis
Gao et al., J Neurosci 2003
(Nerve Degeneration...) :
Second, rotenone and
LPS synergistically
stimulated the
NADPH oxidase mediated release of the superoxide free radical
Gao et al., FASEB J 2003
(Nerve Degeneration...) :
Mechanistically, microglial NADPH oxidase mediated generation of reactive oxygen species played a pivotal role in the synergistic neurotoxicity : MPTP and
LPS synergistically
stimulated the
NADPH oxidase mediated release of superoxide free radical ; pharmacological inhibition and genetic inactivation of NADPH oxidase prevented superoxide production and the synergistic neurotoxicity
Tatsumi et al., J Appl Physiol 2004
(Ventricular Dysfunction, Left) :
Aminoguanidine, an inhibitor of iNOS, significantly attenuated the
LPS induced
NOx production and contractile dysfunction
Yoshida et al., Biol Pharm Bull 2004
:
Investigation into the O ( 2 ) ( - ) -generating ability of
LPS induced
Nox1 in cell-free reconstitution assays showed that : 1 ) Nox1 is unable to generate O ( 2 ) ( - ) per se; 2 ) the combination of Nox1 with GMC cytosol is insufficient for a significant O ( 2 ) ( - ) generation ; 3 ) the combination with neutrophil cytosol enables Nox1 to act like gp91(phox), i.e., to produce O ( 2 ) ( - ) appreciably in response to myristate stimulation ; 4 ) Nox1 prefers NADPH to NADH under the in vitro assay with neutrophil cytosol plus myristate ( K ( m ) =10.4 microM ) ; 5 ) substitution of neutrophil cytosol by a set of recombinant cytosolic components ( rp67 ( phox ), rp47 ( phox ), Rac2 ) is, however, ineffective and still requires GMC cytosol
Thakur et al., J Leukoc Biol 2006
:
These results demonstrate that chronic ethanol feeding increases
LPS stimulated
NADPH oxidase dependent production of ROS in Kupffer cells
Rozenberg et al., Crit Care 2006
(Cardiomyopathies) :
Myocardial
NOx and NO2 were
increased in a similar fashion by
LPS in young ( both LPS doses ) and senescent rats
Nakahira et al., J Exp Med 2006
:
CO attenuated
LPS induced
NADPH oxidase activity in vitro, potentially by binding to gp91(phox)
Miletic et al., Blood 2007
(Granulomatous Disease, Chronic...) :
Here, we identify the Vav family of Rho guanine nucleotide exchange factors ( GEFs ) as critical mediators of
LPS induced MyD88 dependent activation of Rac2,
NADPH oxidase , and ROI production using mice deficient in Vav1, Vav2, and Vav3
Pacquelet et al., Biochem J 2007
:
IRAK-4 phosphorylated p47phox activated the NADPH oxidase in a cell-free system, and IRAK-4 overexpression increased
NADPH oxidase activity in
response to
LPS
Lin et al., J Agric Food Chem 2007
:
LPS increased the expression of TLR4 in HASMCs, and this effect was
mediated by the activation of nicotinamide adenine dinucleotide phosphate (
NADPH ) oxidase , phosphorylation of intracellular mitogen activated protein kinases ( MAPKs ), and increases in the cytoplasmic level of HuR and TLR4 mRNA stability ... G. biloba extract inhibited LPS induced HASMC proliferation and decreased the expression of TLR4 by inhibiting
LPS induced
NADPH oxidase activation, mRNA stabilization, and MAPK signaling pathways
Deng et al., Zhonghua Xin Xue Guan Bing Za Zhi 2007
:
NOx production by 10 ( -7 ) mol/L and 10 ( -6 ) mol/L ALD increased by 50.0 % and 58.7 % respectively ( P < 0.01 ) and iNOS activity was also significantly increased ( P < 0.01 ) in ALD + RU486 group than that in ALD group. ( 2 )
LPS significantly
increased the
NOx production and iNOS activity ( P < 0.01 ) and these effects were not augmented by adding ALD to LPS ( P > 0.05 ) and SP significantly blocked and RU486 significantly enhanced the effects by LSP and ALD on NOx production and iNOS activity ( P < 0.05 )
Kao et al., J Cardiovasc Pharmacol 2007
(Hypotension...) :
In anesthetized rats,
LPS caused systemic hypotension and increased biochemical factors, nitrate/nitrite (
NOx ), methyl guanidine ( MG ), tumor necrosis factoralpha (TNFalpha), and interleukin-1beta (IL-1beta)
Oh et al., Neurosci Lett 2008
(Anoxia) :
Taken together, these results suggest that
LPS induces HIF-1alpha mRNA expression and activation via
NADPH oxidase and Sp1 in BV2 microglia
Yoo et al., Neurochem Int 2008
(Encephalitis...) :
It also suppressed
LPS+IFN-gamma induced
NADPH oxidase activation and eventually, the inducible form of superoxide production
Rada et al., Contrib Microbiol 2008
:
Nox1 is highly expressed in the colon epithelium, and can be
induced by
LPS or IFN- gamma
Qian et al., J Immunol 2008
(Inflammation) :
Moreover, we demonstrate that TGF-beta1 inhibited
LPS induced
NADPH oxidase ( PHOX ) subunit p47phox translocation from the cytosol to the membrane in microglia within 10 min. Mechanistic studies show that TGF-beta1 fails to protect dopaminergic neurons in cultures from PHOX knockout mice, and significantly reduced LPS induced translocation of the PHOX cytosolic subunit p47phox to the cell membrane
Park et al., Exp Mol Med 2009
:
Resveratrol treatment of macrophages inhibited
LPS induced
Nox1 expression as well as ROS generation, and also suppressed LPS induced MCP-1 mRNA and protein expression
Robinson et al., Free Radic Biol Med 2010
:
Production of NO metabolites (
NOx ) and OPPC activity by RAW 264.7 cells was significantly increased by
stimulation with
lipopolysaccharide (LPS) and interferon gamma (IFNgamma) at pO ( 2 ) ranging from 0.07 to 50 %
Maitra et al., J Biol Chem 2009
:
Mechanistically, we observed that IRAK-1 is required for
LPS induced expression of
NOX-1 , a key component of NADPH oxidase, via multiple transcription factors, including p65/RelA, C/EBPbeta, and C/EBPdelta
Lee et al., J Immunol 2009
(Atherosclerosis...) :
LPS increased
Nox1 promoter activity, and resultant expression of mRNA and protein ...
LPS mediated
Nox1 expression and the responses occurred in a calcium independent phospholipase A(2) ( iPLA ( 2 ) ) -dependent manner ... The iPLA(2)beta-specific inhibitor S-BEL or iPLA(2)beta small interfering RNA attenuated
LPS induced
Nox1 expression, ROS production, and foam cell formation ... These results suggest that the binding of
LPS and TLR4
increases Nox1 expression through the iPLA(2)beta-Akt signaling pathway, and control ROS production and foam cell formation
Kim et al., Immunol Cell Biol 2010
:
LPS caused ROS production in macrophages and
increased the mRNA expression of Nox isoforms Nox1 and
Nox2 by 20-fold and two-fold, respectively ...
LPS caused ROS production in macrophages and
increased the mRNA expression of Nox isoforms
Nox1 and Nox2 by 20-fold and two-fold, respectively
Check et al., Mol Immunol 2010
:
Src kinase participates in
LPS induced activation of
NADPH oxidase ... In mouse macrophage RAW264.7 cells, inhibition of src tyrosine family kinases inhibited
LPS induced activation of
NADPH oxidase , phosphorylation of p47(phox), activation of PI3K and phosphorylation of the TLR4 ... These data suggest that both src kinase and PI3 kinase are involved in
LPS induced
NADPH oxidase activation
Zhang et al., Int Immunopharmacol 2010
(Inflammation) :
Both DMC and Cur could markedly decrease iROS production and the expression of
NADPH oxidase induced by
LPS , with more potent inhibitory activity of DMC
Miyoshi et al., Immunology 2010
(Sepsis) :
We further discovered that NADPH oxidase (Nox) 1 expression in LPS stimulated HUVECs was markedly repressed by IL-8 knockdown, and Nox1 knockdown reduced tissue factor expression, suggesting that the
LPS/IL-8 signalling in endothelial cells was predominantly
mediated by
Nox1
Kim et al., FEBS J 2010
:
Nox1 is
induced by
lipopolysaccharide (LPS) in macrophages, but the expression mechanism is not fully understood ...
LPS induced
Nox1 mRNA expression and reactive oxygen species generation in Raw264.7 cells ... Using bone marrow derived macrophages from toll-like receptor 4 mutant mice, we also tested whether
LPS induced
Nox1 expression is toll-like receptor 4 dependent ... The GSK3beta inhibitor LiCl potentiated
LPS induced
Nox1 expression in accordance with beta-catenin accumulation and nuclear translocation
Lin et al., Br J Pharmacol 2011
:
In addition,
LPS stimulated
NADPH oxidase activation and ROS generation were attenuated by the NADPH oxidase inhibitors diphenyleneiodonium chloride ( DPI ) and apocynin (APO)
Wagner et al., Alcohol Clin Exp Res 2012
:
Alcohol- and
LPS induced increases in lung eNOS,
Nox1 , and Nox4 expression were attenuated by rosiglitazone
Tokuda et al., Antioxid Redox Signal 2012
(Inflammation) :
H ( 2 ) S breathing attenuated
LPS induced increase of plasma ALT activity and
NOx levels and lung MPO activity
Lee et al., Cell communication and signaling : CCS 2012
:
LPS induced
NADPH oxidase activation, ROS production, and p47phox translocation from the cytosol to the membrane, which were reduced by PP1 or c-Src siRNA
Tracey et al., J Pharmacol Exp Ther 1995
:
The ED50 values ( dose that elicited a 50 % inhibition of the
LPS dependent increase in [
NOx ] 6 hr after LPS administration ) for L-NG-monomethylarginine acetate, L-NG-nitroarginine methyl ester and aminoguanidine ( administered 3 hr after LPS ) were 34, 21 and 19 mg/kg in the rat and 32, 5 and 4 mg/kg in the mouse