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IL2 — IL4R
Pathways - manually collected, often from reviews:
-
WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway:
CSF3/EPO/IFNA7/CSH1/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNB1/IL2/OSM/PRL/IFNA7/IFNA7
→
IL3RA/IL2RB/IFNAR1/OSMR/PRLR/IL7R/IL6R/CSF3R/IL2RA/EPOR/IL4R/IL2RG/IFNAR2/GHR
(activation)
Text-mined interactions from Literome
Akbar et al., Eur J Immunol 1991
:
After activation, both subsets up-regulate their IL2 receptor (IL2R) and
IL4R expression, yet IL4 substantially
enhanced the proliferation of the CD4+CD45RA+ but not of the CD4+CD45R0+ T cell subset, while
IL2 increased the proliferation of CD4+CD45R0+ but not of the CD4+CD45RA+ T cells
Foxwell et al., Eur J Immunol 1990
:
However,
up-regulation of
IL 4R by its own ligand or
IL 2 and the growth promoting effect of IL 4 on activated, IL 4R+ T cells were CsA resistant