Gene interactions and pathways from curated databases and text-mining

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IL2 — IL4R

Pathways - manually collected, often from reviews:

  • WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: CSF3/EPO/IFNA7/CSH1/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNB1/IL2/OSM/PRL/IFNA7/IFNA7 → IL3RA/IL2RB/IFNAR1/OSMR/PRLR/IL7R/IL6R/CSF3R/IL2RA/EPOR/IL4R/IL2RG/IFNAR2/GHR (activation)

Text-mined interactions from Literome

Akbar et al., Eur J Immunol 1991 : After activation, both subsets up-regulate their IL2 receptor (IL2R) and IL4R expression, yet IL4 substantially enhanced the proliferation of the CD4+CD45RA+ but not of the CD4+CD45R0+ T cell subset, while IL2 increased the proliferation of CD4+CD45R0+ but not of the CD4+CD45RA+ T cells
Foxwell et al., Eur J Immunol 1990 : However, up-regulation of IL 4R by its own ligand or IL 2 and the growth promoting effect of IL 4 on activated, IL 4R+ T cells were CsA resistant