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ANXA6 — HGF

Text-mined interactions from Literome

Skrtic et al., Endocrinology 1999 : Inhibition of p70S6K activation by rapamycin blocked IGF-1 induced DNA synthesis but not the increase in HGF
Chandrasekher et al., Exp Eye Res 2001 (MAP Kinase Signaling System) : HGF increased p70 S6K activity by 300 % and KGF by about 200 %
Okano et al., Biochem Biophys Res Commun 2003 : The activation of AKT, p70 ( s6k ), and ERK1/2 induced by HGF was abolished by pre-treatment with LY294002, a phosphoinositide 3-OH kinase (PI3K) inhibitor, and U0126, a mitogen activated protein kinase/ERK kinase ( MEK ) inhibitor, respectively
Ishikawa et al., PloS one 2013 : Both temsirolimus and everolimus inhibited the phosphorylation of p70S6K and 4E-BP1, which are downstream targets of the mTOR pathway, and reduced the viability of EGFR mutant lung cancer cells, PC-9, and HCC827, even in the presence of HGF in vitro